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Involvement of brain-derived neurotrophic factor and sonic hedgehog in the spinal cord plasticity after neurotoxic partial removal of lumbar motoneurons.

Involvement of brain-derived neurotrophic factor and sonic hedgehog in the spinal cord plasticity after neurotoxic partial removal of lumbar motoneurons.

Gulino R, Gulisano M (2012) Involvement of brain-derived neurotrophic factor and sonic hedgehog in the spinal cord plasticity after neurotoxic partial removal of lumbar motoneurons. Neurosci Res 73(3):238-247. doi: 10.1016/j.neures.2012.04.010

Summary: In this work the authors created a motoneuron depletion with bilateral 6.0-μg injections of CTB-SAP (Cat. #IT-14) into the medial and lateral gastrocnemius muscles of rats. The results indicate BDNF and sonic hedgehog may collaborate in modulating synaptic plasticity after loss of motoneurons.