Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JFH, Roe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V (2012) Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes. Cereb Cortex 22(7):1690-1697. doi: 10.1093/cercor/bhr254 PMID: 21914633
Summary: Verifying the presence of D-serine in astrocyte vesicles would help resolve whether astrocytes produce rapid gliotransmitter exocytosis for the purpose of neuromodulation. In one of a series of experiments the authors looked at D-serine levels with anti-L-glutamate (Cat. #AB-T08). The results suggest that domains of astrocytes can acquire local Ca2+ increases that trigger glutamate and D-serine release.
Related Products: L-Glutamate Rabbit Polyclonal, Conjugated (Cat. #AB-T08)