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  4. Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes.

Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes.

Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JFH, Roe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V (2012) Immunogold detection of L-glutamate and D-serine in small synaptic-like microvesicles in adult hippocampal astrocytes. Cereb Cortex 22(7):1690-1697. doi: 10.1093/cercor/bhr254

Summary: Verifying the presence of D-serine in astrocyte vesicles would help resolve whether astrocytes produce rapid gliotransmitter exocytosis for the purpose of neuromodulation. In one of a series of experiments the authors looked at D-serine levels with anti-L-glutamate (Cat. #AB-T08). The results suggest that domains of astrocytes can acquire local Ca2+ increases that trigger glutamate and D-serine release.

Related Products: L-Glutamate Rabbit Polyclonal, Conjugated (Cat. #AB-T08)