Lin LH, Nitschke Dragon D, Talman WT (2012) Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat. J Chem Neuroanat 43(2):141-148. doi: 10.1016/j.jchemneu.2012.02.001
Summary: Loss of substance P receptor (SPR)-expressing neurons in the nucleus tractus solitarii (NTS) results in reduced baroreflex strength and unstable arterial pressure. The neuronal population expressing the SPR also expresses several other types of receptors – such as N-methyl-D-aspartate (NMDA), and aalpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic (AMPA) receptors. The authors administered 9 ng of SSP-SAP (Cat. #IT-11) into the NTS and looked for differences in the expression of NMDA and AMPA receptors, as well as several different transporters and neuronal markers. he data suggest that the pathological effects of SSP-SAP lesions result from disruption of other neurotransmission systems than those using the SPR.
Related Products: SSP-SAP (Cat. #IT-11)