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  4. Age-related accumulation of non-heme ferric and ferrous iron in mouse ovarian stroma visualized by sensitive non-heme iron histochemistry.

Age-related accumulation of non-heme ferric and ferrous iron in mouse ovarian stroma visualized by sensitive non-heme iron histochemistry.

Asano Y (2012) Age-related accumulation of non-heme ferric and ferrous iron in mouse ovarian stroma visualized by sensitive non-heme iron histochemistry. J Histochem Cytochem 60(3):229-242. doi: 10.1369/0022155411431734

Summary: The mammalian ovary engages in continuous growth and cellular differentiation as long as the animal is capable of reproduction. During these processes iron ions are released from heme structures; these ions are capable of generating free radicals. The purpose of this study was to investigate non-heme iron distribution in ovarian tissue, and how this distribution changes during aging. Lipid peroxidation was monitored by immunohistochemistry using anti-conjugated malondialdehyde (Cat. #AB-T090). The data indicate that increasing oxidative stress, non-heme iron accumulation in ovarian stromal tissue, and aging are related.

Related Products: Anti-Conjugated Malondialdehyde (Cat. #AB-T090)