Aisa B, Gil-Bea FJ, Marcos B, Tordera R, Lasheras B, Del Rio J, Ramirez MJ (2009) Neonatal stress affects vulnerability of cholinergic neurons and cognition in the rat: Involvement of the HPA axis. Psychoneuroendocrinology 34(10):1495-1505. doi: 10.1016/j.psyneuen.2009.05.003
Summary: Early adverse life events such as maternal separation (MS) can increase vulnerability to psychopathology as an adult. The authors administered bilateral intracerebroventricular 1 µg injections of 192-IgG-SAP (Cat. #IT-01) to MS rats then analyzed choline acetyltransferase and acetylcholinesterase activity. Lesioned animals displayed reduced activity of both of these enzymes, as well as decreased glucocorticoid receptor density. The results suggest that vulnerability of basal forebrain cholinergic cells may be affected by the hypothalamic-pituitary-adrenal axis.
Related Products: 192-IgG-SAP (Cat. #IT-01)