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Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology.

De Bartolo P, Gelfo F, Mandolesi L, Foti F, Cutuli D, Petrosini L (2009) Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology. J Alzheimers Dis 17:177-191. doi: 10.3233/JAD-2009-1035

Summary: Donepezil has been shown to enhance cognitive functioning in both healthy patients and those suffering from dementia. This study examined whether donepezil treatment changes neocortical morphology in healthy or diseased brains. Rats received 4 µg bilateral injections of 192-IgG-SAP (Cat. #IT-01) into the lateral ventricles. Various morphological parameters were analyzed demonstrating that in the absence of cholinergic neurons donepezil prevented the compensatory response rather than enhanced function.

Related Products: 192-IgG-SAP (Cat. #IT-01)