Vetrivelan R, Fuller PM, Tong Q, Lu J (2009) Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci 29:9361-9369. doi: 10.1523/JNEUROSCI.0737-09.2009
Summary: Data concerning rapid-eye movement (REM) motor atonia in rats has not agreed with results seen in large amount of data from cats. Here the authors traced the medullary networks in rats involved with this REM function. 120-300 ng injections of orexin-SAP (Cat. #IT-20) were administered to 6 different sites in the medulla. Ablation of orexin receptor-expressing neurons in one site in the ventromedial medulla resulted in intermittent loss of muscle atonia, indicating that glutaminergic neurons in this area are key components of the REM atonia circuit.
Related Products: Orexin-B-SAP (Cat. #IT-20)