Abbott SB, Stornetta RL, Fortuna MG, Depuy SD, West GH, Harris TE, Guyenet PG (2009) Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats. J Neurosci 29:5806-5819. doi: 10.1523/JNEUROSCI.1106-09.2009
Summary: The retrotrapezoid nucleus (RTN) contains a subpopulation of cells that are thought to function as central respiratory chemoreceptors. The authors used bilateral 22-ng injections of anti-DBH-SAP (Cat. #IT-03) into the lateral horn of the second thoracic segment to investigate this hypothesis. Coupled with data generated by lentivirus-driven transgenic expression of a light-activated cationic channel, it is demonstrated that noncatecholaminergic neurons in the RTN function as central respiratory chemoreceptors.
Related Products: Anti-DBH-SAP (Cat. #IT-03)