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  4. Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons.

Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons.

Little CM, Coons KD, Sengelaub DR (2009) Neuroprotective effects of testosterone on the morphology and function of somatic motoneurons following the death of neighboring motoneurons. J Comp Neurol 512:359-372. doi: 10.1002/cne.21885

Summary: ´╗┐Atrophy of androgen-sensitive motoneurons due to proximity to damaged motoneurons can be attenuated by testosterone. This work examined whether typical motoneurons respond in the same way. Rats received 5-ng injections of CTB-SAP (Cat. #IT-14) that eliminated motoneurons innervating the vastus medialis muscle. Partial motoneuron depletion resulted in atrophy of the remaining quadriceps motoneurons; this was attenuated by the administration of testosterone.

Related Products: CTB-SAP (Cat. #IT-14)

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