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  4. Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican.

Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican.

Bogen O, Dina OA, Gear RW, Levine JD (2009) Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. Neuroscience 159:780-786. doi: 10.1016/j.neuroscience.2008.12.049

Summary: Monocyte chemoattractant protein 1 (MCP-1) is involved in generation of inflammatory and neuropathic pain, but the mechanisms underlying this involvement are not understood. Rats received 3.2 µg intrathecal injections of IB4-SAP (Cat. #IT-10). Ten days later the rats received intradermal MCP-1. Animals treated with IB4-SAP did not exhibit the mechanical hyperalgesia normally seen when treated with MCP-1.

Related Products: IB4-SAP (Cat. #IT-10)