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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-κB signaling.

Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-κB signaling. J Biol Chem 280(48):40364-40374. doi: 10.1074/jbc.M509329200

Usage: To eliminate microglia in mixed cortical cultures, cultures were treated with either Ac-LDL-SAP at 3 ug/ml for 18 h or 5mM leucine methyl ester for 12 h. These agents selectively kill microglia in mixed cultures.

Related Products: Acetylated LDL-SAP (Cat. #IT-08)

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