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  4. Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat.

Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat.

Ferry B, Herbeaux K, Cosquer B, Traissard N, Galani R, Cassel JC (2007) Immunotoxic cholinergic lesions in the basal forebrain reverse the effects of entorhinal cortex lesions on conditioned odor aversion in the rat. Neurobiol Learn Mem 88:114-126. doi: 10.1016/j.nlm.2007.01.007

Summary: The entorhinal cortex (EC) is intimately involved in olfactory learning. Lesioning of this structure produces septo-cholinergic sprouting. Rats that had previously received EC lesions were treated with 5-µg intracerebroventricular injections of 192-IgG-SAP (Cat. #IT-01). The results point to a role for hippocampal cholinergic neurons in the modulation of memory processes involved with conditioned odor aversion.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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