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Intrastriatal Administration

Q: Is there is any indication that intrastriatal administration of 192-IgG-SAP (Cat. #IT-01) will lesion the cholinergic neurons of the striatum. My sense from reviewing the literature is that these cholinergic neurons are not susceptible to the toxin, but I thought I’d ask to see if you had any information / experience regarding this point.

A: No, I don’t think it will work because the target of 192-IgG-SAP is p75, LNGFr, which is only expressed on the rat basal forebrain cholinergic neurons. Those striatal neurons don’t express p75 in the adult. The NK1r is often expressed in the striatum, and you can use SSP-SAP (Cat. #IT-11) for them, but that’s the best we can do right now.

Related: 192-IgG-SAP (Cat. #IT-01), SSP-SAP (Cat. #IT-11)