Author name: Kristen Hartman

Possible contribution of cerebellar disinhibition in epilepsy

Ming X, Prasad N, Thulasi V, Elkins K, Shivamurthy VKN (2021) Possible contribution of cerebellar disinhibition in epilepsy. Epilepsy Behav 118:107944. doi: 10.1016/j.yebeh.2021.107944 Summary: The authors hypothesize that loss of inhibition from the cerebellum can lead to cortical activation and seizures. An animal study showed microinjection of SSP-SAP produced a selective ablation of hippocampal inhibitory […]

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Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling.

Gonzalez EA, Leitão SAT, Dos Santos Soares D, Tavares AMV, Giugliani R, Baldo G, Matte U (2021) Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling. J Inherit Metab Dis 44(3):740-750. doi: 10.1002/jimd.12327 PMID: 33145772 Objective: To investigate whether the pathways influenced by losartan and propranolol may modulate the cardiac remodeling

Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling. Read More »

Autosomal recessive osteopetrosis: mechanisms and treatments

Penna S, Villa A, Capo V (2021) Autosomal recessive osteopetrosis: mechanisms and treatments. Dis Model Mech 14(5):dmm048940. doi: 10.1242/dmm.048940 Summary: Autosomal recessive osteopetrosis (ARO) is a severe inherited bone disease characterized by defective osteoclast resorption or differentiation. Novel therapeutic approaches are needed for ARO patients. The authors review preclinical and proof-of-concept studies, such as gene

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An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect.

Loftén A, Adermark L, Ericson M, Söderpalm B (2021) An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect. Addict Biol 26(3):e12959. doi: 10.1111/adb.12959 Summary: Basal extracellular levels of dopamine within the nucleus accumbens are not sustained by muscarinic acetylcholine, whereas accumbal Cholinergic interneurons-ACh are involved in mediating ethanol-induced dopamine release.

An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect. Read More »

Exploring early therapeutic approaches in a mucopolysaccharidosis type I (MPSI) mouse model

De Pontia G (2021) Exploring early therapeutic approaches in a mucopolysaccharidosis type I (MPSI) mouse model. Univ Milan-Bicocca Thesis. Objective: Author applied hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy (ERT) treatments, individually or in combination, during the neonatal period, to evaluate the outcomes in a Mucopolysaccharidosis type I (MPS-I) mouse model. Summary: Although

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Placenta: A gold mine for translational research and regenerative medicine

Pethe P, Kale V (2021) Placenta: A gold mine for translational research and regenerative medicine. Reprod Biol 21(2):100508. doi: 10.1016/j.repbio.2021.100508 Objective: To review recent studies regarding the therapeutic potential of human placenta-derived mesenchymal stromal/stem cells (hPMSCs) and their extracellular vesicles (EVs). Summary: These studies demonstrate salutary effects of hPMSC-EVs on a range of different difficult-to-treat

Placenta: A gold mine for translational research and regenerative medicine Read More »

Medullary noradrenergic neurons mediate hemodynamic responses to osmotic and volume challenges

Marques SM, Naves LM, Silva TME, Cavalcante KVN, Alves JM, Ferreira-Neto ML, de Castro CH, Freiria-Oliveira AH, Fajemiroye JO, Gomes RM, Colombari E, Xavier CH, Pedrino GR (2021) Medullary noradrenergic neurons mediate hemodynamic responses to osmotic and volume challenges. Front Physiol 12:649535. doi: 10.3389/fphys.2021.649535 Summary: The study sought to determine the role of noradrenergic neurons

Medullary noradrenergic neurons mediate hemodynamic responses to osmotic and volume challenges Read More »

Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae ameliorates hypertensive renal damage

Hou G, Jiang Y, Zheng Y, Zhao M, Chen Y, Ren Y, Wang C, Li W (2021) Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae ameliorates hypertensive renal damage. Biomed Res Int eCollection:5598351. doi: 10.1155/2021/5598351 PMID: 33969119 Objective: To explore the mechanism of combination of Radix Astragali (RA) and Radix Salviae Miltiorrhizae (RS) ameliorating HRD

Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae ameliorates hypertensive renal damage Read More »

Dissection and surgical approaches to the mouse jugular-nodose ganglia

Han W, de Araujo IE (2021) Dissection and surgical approaches to the mouse jugular-nodose ganglia. STAR Protocols 2(2):100474. doi: 10.1016/j.xpro.2021.100474 Usage: Injected 0.5 µl of CCK-SAP (250 ng/µl) into the R-NG of VGlut2-ires-Cre mice. Related Products: CCK-SAP (Cat. #IT-31) For complete details on the use and execution of this protocol, please refer to Han et

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