Author name: Kristen Hartman

Cholinergic modulation of dopamine-related effects of ethanol in the rat

Loften A (2024) Cholinergic modulation of dopamine-related effects of ethanol in the rat. Univ Gothenburg Thesis. Objective: To explore the role of acetylcholine and cholinergic interneurons (CIN) in ethanol-induced dopamine (DA) release and in the reinforcing effects of ethanol. Summary: The author’s thesis supports an important role of accumbal CIN in ethanol ́s DA releasing […]

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Where does the saporin payload release after internalization?

Question: Where does the saporin payload release after internalization? For example, does it require trafficking into a late endosome/lysosomal compartment?  Answer: Thank you for reaching out to us. Hopefully I can help answer some of your questions regarding what happens to saporin after being internalized.  I would first like to refer you to an article we

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Longitudinal assessment of outcome measures of diaphragm motor unit connectivity as biomarkers of phrenic motor unit degeneration and compensation

Ketabforoush A, Wang M, Smith C, Arnold WD, Nichols N (2024) Longitudinal assessment of outcome measures of diaphragm motor unit connectivity as biomarkers of phrenic motor unit degeneration and compensation. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.1402 Objective: Using CTB-SAP to lesion motor neurons and measuring motor neuron connectivity and cell death, as a model for

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Cardiorespiratory disturbances in Alzheimer’s disease: A focus on the contribution of sympathetic premotor neurons

Toledo C, Del Rio R (2024) Cardiorespiratory disturbances in Alzheimer’s disease: A focus on the contribution of sympathetic premotor neurons. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.2540 Objective: To characterize cardiorespiratory function in AD patients and then to determine the role of RVLM-C1 neurons in autonomic and sleep-disordered breathing in APP/PS1 double transgenic mice, and experimental

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Melanopsin ganglion cells in the mouse retina independently evoke pupillary light reflex

Bohl JM, Hassan AR, Sharpe ZJ, Kola M, Ayub M, Pandey Y, Shehu A, Ichinose T (2024) Melanopsin ganglion cells in the mouse retina independently evoke pupillary light reflex. bioRxiv doi: 10.1101/2024.05.14.594181 Objective: To examine the role of rod and cone photoreceptors in pupillary light reflex (PLR) by acutely ablating photoreceptors. Summary: Results demonstrate that

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Flp-recombinase mouse line for genetic manipulation of ipRGCs

Contreras E, Liang C, Mahoney HL, Javier JL, Luce ML, Labastida Medina K, Bozza T, Schmidt TM (2024) Flp-recombinase mouse line for genetic manipulation of ipRGCs. bioRxiv doi: 10.1101/2024.05.06.592761 PMID: 38766000 Objective: To report the generation and characterization of a new mouse line (Opn4FlpO), in which FlpO is expressed from the Opn4 locus, to manipulate

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Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats

Meng XT, Song SY, Li Y, Peng S, Zhang LC (2024) Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats. Research Square doi: 10.21203/rs.3.rs-4258857/v1 Objective: To study the effects of Dexmedetomidine (DEX) on pain modulation. Summary: Dexmedetomidine is an alpha 2-adrenergic receptor agonist with sedative, analgesic, and

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Extra-hippocampal contributions to social memory: The role of septal nuclei

Shivakumar AB, Mehak SF, Jijimon F, Gangadharan G (2024) Extra-hippocampal contributions to social memory: The role of septal nuclei. Biol Psychiatry 6:835-847. doi: 10.1016/j.biopsych.2024.04.018 PMID: 38718881 Objective: Review neural circuit mechanisms that underlie social memory, with a special emphasis on the septum. Summary: Understanding the complexities of the septohippocampal axis will allow targeted therapies to

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Development of chemically induced choroidal injury models for the study and treatment of AMD

Han I, Pandala N, Haefeli L, Lang MJ, Stone EM, Mullins RF, Tucker BA (2024) Development of chemically induced choroidal injury models for the study and treatment of AMD. ARVO Annual Meeting 65(7):5382. Objective: To describe the development of Age-Related Macular Degeneration (AMD) models through the targeted injury of choroidal cells in the eye. Summary:

Development of chemically induced choroidal injury models for the study and treatment of AMD Read More »

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