Tierney ML, Unwin N (2000) Electron microscopic evidence for the assembly of soluble pentameric extracellular domains of the nicotinic acetylcholine receptor. J Mol Biol 303(2):185-196. doi: 10.1006/jmbi.2000.4137 PMID: 11023785 Related Products: Nicotinic Acetylcholine Receptor alpha 1 (mAb 35) Rat Monoclonal (Cat. #AB-N36)
Read the 4th quarter, 2000 Newsletter and recent scientific references CBF Lesioning in Rabbits / by Beach T / featuring ME20.4-SAP, Cat. #IT-15 Chronic Pain Therapeutic NIDA funds ATS research on Galanin Targeting Talk: Second Immunotoxins Targeting Tools: New Products Mouse-Specific p75 Immunotoxin (Cat. #IT-16) ME20.4 Monoclonal and Immunotoxin (Cat. #IT-15, Cat. #AB-N07)
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The ME20.4 monoclonal antibody (Cat. #AB-N07) was derived from immunization of mice with WM245 melanoma cells. The antibody can be used in Western blot, immunoprecipitation, immunohistochemistry, FACS analysis, and electron microscopy. The known species reactivity includes human, primate, rabbit, raccoon, dog, cat, and sheep. The ME20.4-SAP immunotoxin (Cat. #IT-15) is a chemical conjugation between the
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The long-sought mouse cholinergic toxin has been found! The mouse cholinergic immunotoxin (Cat. #IT-16) is being released for sale at the Society for Neuroscience meeting in New Orleans, November 4-9, 2000! For years ATS has received requests for a molecule that would eliminate cholinergic neurons in the basal forebrain of mice in a manner that
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Q: What is a second immunotoxin? A: ATS’s second immunotoxins are conjugations of a secondary antibody (as of December 2000, either goat anti-mouse IgG or goat anti-rabbit IgG) to the ribosome-inactivating protein, saporin. Q: How does a second immunotoxin target? A: The second immunotoxin uses the secondary antibody to “piggyback” onto your primary antibody in
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Gu Z, Wortwein G, Yu J, Perez-Polo JR (2000) Model for aging in the basal forebrain cholinergic system. Antiox Redox Signal 2(3):437-447. doi: 10.1089/15230860050192215 Summary: A wide range of evidence indicates that cholinergic neurons play a role in memory and learning. Loss of these neurons is seen both in aged subjects and Alzheimer’s Disease patients.
Model for aging in the basal forebrain cholinergic system. Read More »
Lappi DA, Wiley RG (2000) Entering through the doors of perception: characterization of a highly selective Substance P receptor-targeted toxin. Neuropeptides 34(5):323-328. doi: 10.1054/npep.2000.0827 Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)
Beach T (2000) Featured Article: CBF lesioning in rabbits. Targeting Trends 1(1) Related Products: ME20.4-SAP (Cat. #IT-15) Read the featured article in Targeting Trends. See Also: Beach TG et al. Cholinergic deafferentation of the rabbit cortex: a new animal model of Abeta deposition. Neurosci Lett 283:9-12, 2000.
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In April of this year ATS applied for funding from National Institute for Mental Health (NIMH) for the toxicology studies of Substance P-Saporin (SP-SAP). This $674,000 supplement to a previous NIMH Small Business Innovative Research grant will cover one of the FDA-required safety and toxicology studies and will bring us closer to clinical trials in
Chronic Pain Therapeutic Read More »
Advanced Targeting Systems (ATS) has just been awarded a $100,000 research grant from the National Institute on Drug Abuse (NIDA). This Phase I SBIR (Small Business Innovation Research) grant proposes to develop a research reagent to study the function of the neuropeptide, galanin. This will be an important tool for scientists to use in the
NIDA funds ATS research on Galanin Read More »