Author name: Kristen Hartman

Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats.

Scattoni ML, Adriani W, Calamandrei G, Laviola G, Ricceri L (2006) Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats. Behav Pharmacol 17(5-6):517-524. doi: 10.1097/00008877-200609000-00018 Summary: Work in the last decade has focused on clarifying the role of cholinergic dysfunction in Alzheimer’s disease. 7 day-old rats received 0.21 […]

Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats. Read More »

Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons.

Rygh LJ, Suzuki R, Rahman W, Wong Y, Vonsy JL, Sandhu H, Webber M, Hunt S, Dickenson AH (2006) Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons. Eur J Neurosci 24(3):761-772. doi: 10.1111/j.1460-9568.2006.04968.x Summary: Long-term potentiation (LTP) has been shown to occur in sensory areas of the spinal cord. This

Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons. Read More »

Neurokinin-1 receptor expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat.

Nattie E, Li A (2006) Neurokinin-1 receptor expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat. J Appl Physiol 101(6):1596-1606. doi: 10.1152/japplphysiol.00347.2006 Summary: All known chemoreceptor sites in the mammalian brainstem are rich in the neurokinin-1 receptor (NK1r). The authors ask if these cells scattered throughout

Neurokinin-1 receptor expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat. Read More »

CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

Adam PJ, Terrett JA, Steers G, Stockwin L, Loader JA, Fletcher GC, Lu LS, Leach BI, Mason S, Stamps AC, Boyd RS, Pezzella F, Gatter KC, Harris AL (2006) CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer 95(3):298-306. doi: 10.1038/sj.bjc.6603222 Summary: Renal

CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Read More »

Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance p in the striatum of mice

Zhu JP, Xu W, Angulo JA (2006) Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance p in the striatum of mice. Ann N Y Acad Sci 1074:135-148. doi: 10.1196/annals.1369.013 PMID: 17105911 Objective: To investigate the mechanism by which substance P mediates METH-induced damage. Summary: The authors propose that substance

Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance p in the striatum of mice Read More »

Adenosine and sleep homeostasis in the basal forebrain.

Blanco-Centurion C, Xu M, Murillo-Rodriguez E, Gerashchenko D, Shiromani AM, Salin-Pascual RJ, Hof PR,Shiromani PJ (2006) Adenosine and sleep homeostasis in the basal forebrain. J Neurosci 26(31):8092-8100. doi: 10.1523/JNEUROSCI.2181-06.2006 Summary: It has been shown that adenosine induces sleep and levels of adenosine increase during times of wakefulness. The authors investigated whether basal forebrain cholinergic neurons

Adenosine and sleep homeostasis in the basal forebrain. Read More »

Somatostatin presynaptically inhibits both GABA and glutamate release onto rat basal forebrain cholinergic neurons.

Momiyama T, Zaborszky L (2006) Somatostatin presynaptically inhibits both GABA and glutamate release onto rat basal forebrain cholinergic neurons. J Neurophysiol 96(2):686-694. doi: 10.1152/jn.00507.2005 PMID: 16571735 Related Products: 192-IgG Mouse Monoclonal, Cy3-labeled (Cat. #AB-N43FL3)

Somatostatin presynaptically inhibits both GABA and glutamate release onto rat basal forebrain cholinergic neurons. Read More »

Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization.

Vera-Portocarrero LP, Zhang ET, Ossipov MH, Xie JY, King T, Lai J, Porreca F (2006) Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Neuroscience 140(4):1311-1320. doi: 10.1016/j.neuroscience.2006.03.016 Summary: Rats were treated with 1.5 pmol of dermorphin-SAP (Cat. #IT-12) or saporin (Cat. #PR-01) into each side of the rostral ventromedila medulla, followed

Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization. Read More »

Selective cholinergic immunolesioning in alpha7 nAChR KO mice: Anatomical, neurochemical and functional effects

Ledri M, Cusulin C, Novati A, Aztiria E, Leanza G (2006) Selective cholinergic immunolesioning in alpha7 nAChR KO mice: Anatomical, neurochemical and functional effects. FENS 2006 Abstracts 3:A1610.10. Federation of European Neuroscience Societies, Vienna, Austria. Related Products: mu p75-SAP (Cat. #IT-16)

Selective cholinergic immunolesioning in alpha7 nAChR KO mice: Anatomical, neurochemical and functional effects Read More »

Retrograde Transport

Q: I have a question about Retrograde Transport. There is a comment in the FAQ “In fact, we recommend that you wait two weeks at least to see immunohistological evidence of a toxic effect after injection of a saporin toxin in vivo.” Are there data to support this recommendation? As a researcher who utilizes your

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