Frielingsdorf H, Thal LJ, Pizzo DP (2006) The septohippocampal cholinergic system and spatial working memory in the Morris water maze. Behav Brain Res 168(1):37-46. doi: 10.1016/j.bbr.2005.10.008 Summary: The authors examined whether an optimized Morris water maze test could reveal the role of the septohippocampal cholinergic system in spatial working memory. Rats were treated with bilateral […]
Parikh V, Sarter M (2006) Cortical choline transporter function measured in vivo using choline-sensitive microelectrodes: clearance of endogenous and exogenous choline and effects of removal of cholinergic terminals. J Neurochem 97(2):488-503. doi: 10.1111/j.1471-4159.2006.03766.x Summary: A major projection of brain attention systems passes through the cholinergic portion of the cortical mantle. The authors investigated the role
Weyergang A, Selbo PK, Berg K (2006) Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin. J Control Release 111(1-2):165-173. doi: 10.1016/j.jconrel.2005.12.002 Summary: In this study the authors investigated the use of photosensitizers located in endocytic vesicles that can be induced to release macromolecules upon activation by light. This process is called photochemical
DiLillo DJ, Pawluczkowycz AW, Peng W, Kennedy AD, Beum PV, Lindorfer MA, Taylor RP (2006) Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b. Mol Immunol 43(7):1010-1019. doi: 10.1016/j.molimm.2005.05.003 PMID: 15961157 Related Products: Antibody to Complement C3 (1H8) (Cat. #AB-V83)
Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL (2006) Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Toxicol Sci 91(1):286-298. doi: 10.1093/toxsci/kfj143 Summary: SP-SAP (Cat. #IT-07) has been shown to reverse neuropathic pain behavior in rodents and prevent
Safety evaluation of Intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Read More »
Foehr ED, Lorente G, Kuo J, Ram R, Nikolich K, Urfer R (2006) Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. Cancer Res 66(4):2271-2278. doi: 10.1158/0008-5472.CAN-05-1221 Summary: The receptor protein tyrosine phosphatase ß (RPTPß) is overexpressed in astrocytomas, and is a potential target for
Easton A, Dwyer E, Pfaff DW (2006) Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice. Behav Neurosci 120(1):1-9. doi: 10.1037/0735-7044.120.1.1 Summary: Many aspects of female behavioral arousal in response to estrogens are not yet well understood. Here the authors examine the role of orexins as targets for estrogens. Female
O’Connell PJ, Wang X, Leon-Ponte M, Griffiths C, Pingle SC, Ahern GP (2006) A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood 107(3):1010-1017. doi: 10.1182/blood-2005-07-2903 PMID: 16223770 Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09)
Saenz C, Dominguez R, de Lacalle S (2006) Estrogen contributes to structural recovery after a lesion. Neurosci Lett 392(3):198-201. doi: 10.1016/j.neulet.2005.09.023 Summary: The authors evaluated the trophic effects of 17ß-estradiol (E2) on cholinergic neurons of the basal forebrain after lesioning with 192-IgG-SAP (Cat. #IT-01). Ovariectomized female rats received 200 nl of 0.075 mg/ml 192-IgG-SAP followed
Estrogen contributes to structural recovery after a lesion. Read More »
Li A, Nattie E (2006) Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol 570(Pt 2):385-396. doi: 10.1113/jphysiol.2005.099325 Summary: Brainstem catecholamine (CA) neurons are thought to modulate the processing of sensory information and participate in the control of breathing. Using a 5 µg injection of anti-DBH-SAP (Cat. #IT-03), or a