Author name: Kristen Hartman

Hypocretin-1 stimulates wake and decreases sleep in the basal forebrain of rats with 192-IgG-sap induced lesion of the cholinergic neurons

Blanco-Centurion CA, Shiromani PJ (2006) Hypocretin-1 stimulates wake and decreases sleep in the basal forebrain of rats with 192-IgG-sap induced lesion of the cholinergic neurons. Neuroscience 2006 Abstracts 458.7. Society for Neuroscience, Atlanta, GA. Summary: Hypocretin (orexin) containing neurons are located in the lateral hypothalamus (LH) from where they project to major arousal centers in […]

Hypocretin-1 stimulates wake and decreases sleep in the basal forebrain of rats with 192-IgG-sap induced lesion of the cholinergic neurons Read More »

An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence.

Keener WK, Rivera VR, Young CC, Poli MA (2006) An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence. Anal Biochem 357(2):200-207. doi: 10.1016/j.ab.2006.07.005 Summary: The authors use synthetic biotinylated RNA substrates to assay adenine-specific RNA N-glycosidases, one of which is saporin (Cat. #PR-01). The RNA substrates are annealed to a ruthenylated oligodeoxynucleotide,

An activity-dependent assay for ricin and related RNA N-glycosidases based on electrochemiluminescence. Read More »

Selective 192 IgG-saporin lesions of the cholinergic basal forebrain impair negative patterning discrimination learning in rats

Cortez AM, Amodeo D, Chavez C, Flesher M, Balbous M, Butt AE (2006) Selective 192 IgG-saporin lesions of the cholinergic basal forebrain impair negative patterning discrimination learning in rats. Neuroscience 2006 Abstracts 162.7. Society for Neuroscience, Atlanta, GA. Summary: We have previously argued that the cholinergic nucleus basalis magnocellularis (NBM) is necessary for complex or

Selective 192 IgG-saporin lesions of the cholinergic basal forebrain impair negative patterning discrimination learning in rats Read More »

Steroid sulfatase inhibitor (p-O-sulfamoyl) – tetradecanoyl tyramine (du-14) enhances memory retention in rats with cholinergic lesion

Abitoye PA, Li P, Gibbs RB, Johnson DA (2006) Steroid sulfatase inhibitor (p-O-sulfamoyl) – tetradecanoyl tyramine (du-14) enhances memory retention in rats with cholinergic lesion. Neuroscience 2006 Abstracts 163.15. Society for Neuroscience, Atlanta, GA. Summary: Previous studies have shown that altering the metabolism of neurosteroids via inhibition of steroid sulfatase (SSI) would reverse scopolamine induced

Steroid sulfatase inhibitor (p-O-sulfamoyl) – tetradecanoyl tyramine (du-14) enhances memory retention in rats with cholinergic lesion Read More »

Ascending and descending pathways support fentanyl-induced pain hypersensitivity with and without a surgical incision

Rivat C, Vera-Portocarrero LP, Ibrahim MM, Mata HP, Stagg NJ, De Felice M, Porreca F, Malan TP (2006) Ascending and descending pathways support fentanyl-induced pain hypersensitivity with and without a surgical incision. Neuroscience 2006 Abstracts 248.10. Society for Neuroscience, Atlanta, GA. Summary: Acutely administered the analgesic opioid fentanyl has been shown to enhance mechanical hypersensitivity

Ascending and descending pathways support fentanyl-induced pain hypersensitivity with and without a surgical incision Read More »

Brain-derived neurotrophic growth factor from p75-expressing sensory afferents drives spinal noradrenergic fiber sprouting following nerve injury in rats

Hayashida K, Clayton B, Ma W, Eisenach J (2006) Brain-derived neurotrophic growth factor from p75-expressing sensory afferents drives spinal noradrenergic fiber sprouting following nerve injury in rats. Neuroscience 2006 Abstracts 248.19. Society for Neuroscience, Atlanta, GA. Summary: We previously showed that peripheral nerve injury in mice results in sprouting of noradrenergic (NA) fibers in the

Brain-derived neurotrophic growth factor from p75-expressing sensory afferents drives spinal noradrenergic fiber sprouting following nerve injury in rats Read More »

Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat

Tait DS, Brown VJ, Farovik A, Theobald DE, Dalley JW, Robbins TW (2006) Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat. Neuroscience 2006 Abstracts 264.4. Society for Neuroscience, Atlanta, GA. Summary: Rats with medial prefrontal cortex (mPFC) lesions are impaired in attentional set shifting (Birrell and Brown, 2000, J Nsci, 20:4320-4324).

Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat Read More »

Cholinergic immunolesioning produced tangle-like inclusions in TgCRND8 brain

Chauhan NB (2006) Cholinergic immunolesioning produced tangle-like inclusions in TgCRND8 brain. Neuroscience 2006 Abstracts 271.8. Society for Neuroscience, Atlanta, GA. Summary: Today’s Alzheimer’s disease (AD) research lacks a “complete” model that would represent both plaque and tangle pathology together with correlative memory deficits. Although currently developed transgenic model including APP/PS1/tau mutations do not “truly” represent

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SFN Poster of the Year 2006

Awarded by ATS at Society for Neuroscience (SFN) Atlanta, GA • October 14-18, 2006 Be sure to check out the cover article contributed by Dr. Chauhan in our Targeting Trends newsletter (First Quarter, 2007). 271.8 Cholinergic immunolesioning produced tangle-like inclusions in TgCRND8 brain*N.B.Chauhanfeaturing IT-16 mu p75-SAP (Poster) Today’s Alzheimer’s disease (AD) research lacks a “complete” model

SFN Poster of the Year 2006 Read More »

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