Flash Calendar Event Coming Soon 2024
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A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats
Masmudi-Martín M, López-Aranda MF, Navarro-Lobato I, Khan ZU (2024) A role of frontal association cortex in long-term object recognition memory of objects with complex features in rats. Eur J Neurosci doi: 10.1111/ejn.16243 PMID: 38238909 Objective: Provide evidence that the frontal association cortex and not the Perirhinal cortex is essential for object recognition memory (ORM) of
Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin
Allred CA, Gormley C, Venugopal I, Li S, McGuire MJ, Brown KC (2023) Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin. Commun Biol 6(1):60. doi: 10.1038/s42003-022-04385-7 PMID: 36650239 Objective: The demonstration of a peptide optimized by chemical modifications for tumor specificity to deliver saporin, a catalytic toxin, specifically to cancer cells via both in
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Jan 2024 Game
Play the January puzzleto win a 2024 ATS Wall Calendar! ATS wishes you a wonderful 2024 and looks forward to helping you with your targeting needs. Thank you for playing!
New methods to investigate the GnRH pulse generator
Ivanova D, O’Byrne KT (2024) New methods to investigate the GnRH pulse generator. J Mol Endocrinol 72(2):e230079. doi: 10.1530/JME-23-0079 PMID: 38085702 Objective: To review the latest methodologies and insights into the GnRH pulse generator and its role in regulating reproductive hormone secretion. Summary: The paper discusses recent advancements in understanding the GnRH pulse generator and
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Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice
Maiarù M, Leese C, Silva-Hucha S, Fontana-Giusti S, Tait L, Tamagnini F, Davletov B, Hunt SP (2024) Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice. J Pain 11 doi: 10.1016/j.jpain.2024.01.331 PMID: 38218509
Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells
Gong S, Qiu J, Thayumanavan S (2023) Self-assembly of epitope-tagged proteins and antibodies for delivering biologics to antigen presenting cells. J Am Chem Soc doi: 10.1021/jacs.3c09334 PMID: 38147631 Objective: To describe a simple self-assembly strategy for generating artificial immune complexes. Summary: The built-in recognition domains in the antibody, viz. the Fab and Fc domains, are
Heterophyllin: A new adenia toxic lectin with peculiar biological properties
Bortolotti M, Biscotti F, Zanello A, Polito L, Bolognesi A (2024) Heterophyllin: A new adenia toxic lectin with peculiar biological properties. Toxins 16(1):1. doi: 10.3390/toxins16010001 Objective: Describe the novel type II Ribosome Inactivating Protein, Heterophyllin. Summary: Heterophyllin, a novel toxic lectin from Adenia heterophylla shows enzymatic and lectin properties of type 2 RIPs. Heterophyllin was
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Intracellular protein delivery: Approaches, challenges, and clinical applications
Chan A, Tsourkas A (2024) Intracellular protein delivery: Approaches, challenges, and clinical applications. BME Frontiers doi: 10.34133/bmef.0035 Objective: To review progress made towards achieving cytosolic delivery of recombinant proteins and possible strategies to enable proteins to cross cell membranes. Summary: Drug delivery researchers have worked to deliver saporin into tumor cells in the hopes of
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Immunomodulatory impact of memory T lymphocyties in periodontitis
de Paula FS (2023) Immunomodulatory impact of memory T lymphocyties in periodontitis. Univ Minnesota Thesis. Objective: This thesis paper sought to determine whether local reactivation of oral tissue resident memory cells (TRM) of a defined antigen specificity could exacerbate ligature-induced periodontal (LIP), a model for periodontal disease in mice. Summary: Reactivation of oral TRM aggravated
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