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Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems
Berselli E, Coccolini C, Tosi G, Gokce EH, Oliveira MBPP, Fathi F, Krambeck K, Suoto EB (2024) Therapeutic peptides and proteins: Stabilization challenges and biomedical applications by means of nanodelivery systems. Int J Pept Res Ther 30:15. doi: 10.1007/s10989-024-10592-z
Objective: To discuss the stability problems of proteins and peptides that have driven the scientific community to find in nanotechnology a valid alternative for oral administration of biomolecules.
Summary: Nanoparticles have been proposed to improve the gastrointestinal stability of such macromolecules and, thus, their oral bioavailability. It has also been shown that combining different approaches, such as liposomes and hydrophobic ion pairing and hybrid systems made of polymers and lipids, may lead to synergistic advantages in modifying the release profile and the uptake of peptides/proteins through the gut.
Usage: See Fu et al. (2022). This publication showed an efficient result of a nano-encapsulated protein for cancer therapy. They encapsulate da tetra-guanidinium (TG)-modified saporin into tumor microenvironment (TME) pH-responsive polymeric NP.
Related Products: Saporin (Cat. #PR-01)
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Exploring the potential of nanogels: From drug carriers to radiopharmaceutical agents
Kubeil M, Suzuki Y, Casulli MA, Kamal R, Hashimoto T, Bachmann M, Hayashita T, Stephan H (2023) Exploring the potential of nanogels: From drug carriers to radiopharmaceutical agents. Adv Healthc Mater e2301404. doi: 10.1002/adhm.202301404 PMID: 37717209
Summary: This review provides a brief overview of current developments of nanogels in the fields of drug delivery, therapeutic applications, tissue engineering and sensor systems. The authors described one development using saporin. Mimicking the function of molecular chaperones, Kawasaki et al. created magnetic in vivo protein transport nanogels with encapsulated iron oxide nanoparticles. The nanogels also contained saporin, which was rapidly released by an exchange reaction with serum protein. The evaluation using an oral cancer model revealed a reduction in tumor volume and suppression of tumor regrowth, with no change in body weight.
Related Products: Saporin (Cat. #PR-01)
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Self-assembled nanogels consisting of cholesterol-bearing polysaccharides and their applications in medicine
Antonia-Nancy H, Matsumoto M, Tahara Y (2023) Self-assembled nanogels consisting of cholesterol-bearing polysaccharides and their applications in medicine. (eds. Dr. Chukwuebuka Emmanuel Umeyor, Dr. Emmanuel Uronnachi and Dr. Pratik Kakade). In: Hydrogels and Nanogels – Applications in Medicine doi: 10.5772/intechopen.1001981
Objective: Using iron oxide-containing nano-gels containing saporin to magnetically guide the targeting of saporin.
Summary: Nanogels containing inorganics are an emerging tool to direct the targeting of drugs within the body. Saporin was bound in a cholesterol-bearing pullulan nanogel with particles of iron oxide was magnetically steered through the chaperoning gel to treat a model of oral cancer.
Usage: Using Saporin bound to magnetic nanogel to target a model of oral cancer. See Also: Saporin usage form these two papers: KawasakiR, SasakiY, KatagiriK, MukaiS-A, SawadaS-I, AkiyoshiK. Magnetically guided protein transduction by hybrid Nanogel chaperones with iron oxide nanoparticles. Angewandte Chemie, International Edition. 2016;55:11377-11381.DOI:10.1002/anie.201602577 KawasakiR, SasakiY, NishimuraT, KatagiriK, MoritaK-I, SekineY, etal. Magnetically navigated protein transduction In vivo using iron oxide-Nanogel chaperone hybrid. Advanced Healthcare Materials. 2021;10:2001988.DOI:10.1002/adhm.202001988
Related Products: Saporin (Cat. #PR-01)
Magnetically navigated protein transduction in vivo using iron oxide-nanogel chaperone hybrid
Kawasaki R, Sasaki Y, Nishimura T, Katagiri K, Morita KI, Sekine Y, Sawada SI, Mukai SA, Akiyoshi K (2021) Magnetically navigated protein transduction in vivo using iron oxide-nanogel chaperone hybrid. Adv Healthc Mater 10(9):e2001988. doi: 10.1002/adhm.202001988
Summary: A magnetically guided in vivo protein transduction is demonstrated using magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and a polysaccharide nanogel, a protein carrier inspired by “catch and release” mechanisms of MCs. In an oral cancer model, MC-delivered magnetically targeted saporin decreased tumor volume without significant body weight changes and no regrowth of tumor at 3 months after complete regression.