Targeting Trends Newsletter 13q2

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Newsletter Highlights

  • Spring Brain Conference Highlights (page 2)
  • Targeting Talk: FGF-SAP and FabFc-ZAP (page 5)
  • FabFc-ZAP: A new secondary conjugate (page 7)
  • Complete and Submit the Targeting Teaser online!

Antibodies to glycosphingolipids: An attractive tool for targeted delivery of cytotoxic agents to tumor cells (continued on page 6)

Contributed by Jose Luis Daniotti, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC, UNC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Product information related to cover article: Mab-ZAP (Cat. #IT-04)

Spring Brain Conference Highlights

Recent Scientific References (read summaries)

  • Ren C, Luan L, Wui-Man Lau B, Huang X, Yang J, Zhou Y, Wu X, Gao J, Pickard GE, So KF, Pu M. (2013) Direct Retino-Raphe Projection Alters Serotonergic Tone and Affective Behavior. Neuropsychopharmacology Epub (Cat. #IT-44, IT-27)
  • Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJr, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. (2013) Stable Respiratory Activity Requires Both P/Q-Type and N-Type Voltage-Gated Calcium Channels. J Neurosci 33(8):3633-3645. (Cat. #AB-N33AP)
  • Shia WW, Bailey RC. (2013) Single domain antibodies for the detection of ricin using silicon photonic microring resonator arrays. Anal Chem 85(2):805-810. (Cat. #AB-17AP)
  • Ferrini F, Trang T, Mattioli TA, Laffray S, Del’Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. (2013) Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl(-) homeostasis. Nat Neurosci 16(2):183-192. (Cat. #IT-33, PR-01)
  • Brayda-Bruno L, Mons N, Yee BK, Micheau J, Abrous DN, Nogues X, Marighetto A. (2013) Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits. Neurobiol Dis 54:372-381. (Cat. #IT-16)
  • Hamlin AS, Windels F, Boskovic Z, Sah P, Coulson EJ. (2013) Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation. PLoS One 8(1):e53472. (Cat. #IT-16, IT-35)
  • Ramos-Rodriguez JJ, Pacheco-Herrero M, Thyssen D, Murillo-Carretero MI, Berrocoso E, Spires-Jones TL, Bacskai BJ, Garcia-Alloza M. (2013) Rapid beta-Amyloid Deposition and Cognitive Impairment After Cholinergic Denervation in APP/PS1 Mice. J Neuropathol Exp Neurol 72(4):272-285. (Cat. #IT-16)
  • Torres Demichelis V, Vilcaes AA, Iglesias-Bartolome R, Ruggiero FM, Daniotti JL. (2013) Targeted Delivery of Immunotoxin by Antibody to Ganglioside GD3: A Novel Drug Delivery Route for Tumor Cells. PLoS One 8(1):e55304. (Cat. #IT-04)
  • Zheng H, Rinaman L. (2013) Yohimbine anxiogenesis in the elevated plus maze requires hindbrain noradrenergic neurons that target the anterior ventrolateral bed nucleus of the stria terminalis. Eur J Neurosci 37(8):1340-1349. (Cat. #IT-03)
  • Szigeti C, Bencsik N, Simonka AJ, Legradi A, Kasa P, Gulya K. (2013) Long-term effects of selective immunolesions of cholinergic neurons of the nucleus basalis magnocellularis on the ascending cholinergic pathways in the rat: A model for Alzheimer’s disease. Brain Res Bull 94C:9-16. (Cat. #IT-01)
  • Laplante F, Dufresne MM, Ouboudinar J, Ochoa-Sanchez R, Sullivan RM. (2013) Reduction in cholinergic interneuron density in the nucleus accumbens attenuates local extracellular dopamine release in response to stress or amphetamine. Synapse 67(1):21-29. (Cat. #IT-42, IT-35)
  • Lin LH, Nitschke Dragon D, Talman WT. (2012) Collateral damage and compensatory changes after injection of a toxin targeting neurons with the neurokinin-1 receptor in the nucleus tractus solitarii of rat. J Chem Neuroanat 43(2):141-148. (Cat. #IT-11)
  • Kato J, O’Donnell RT, Abuhay M, Tuscano JM. (2012) Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin’s lymphoma. Oncoimmunology 1(9):1469-1475. (Cat. #IT-18)
  • Talman WT, Lin LH. (2013) Sudden death following selective neuronal lesions in the rat nucleus tractus solitarii. Auton Neurosci 175(1-2):9-16. (Cat. #IT-11, IT-03)
  • Mavrogenis AF, Pavlakis K, Stamatoukou A, Papagelopoulos PJ, Theoharis S, Zetahang Z, Soucacos PN, Zoubos AB. (2013) Intraneural OX7-saporin for neuroma-in-continuity in a rat model. Eur J Orthop Surg Traumatol 23(3):263-272. (Cat. #IT-02)
  • Kukkonen JP. (2013) Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol 304(1):C2-32. (Cat. #IT-20)

Targeting Talk: Product Questions

Targeting Teaser Solution

Targeted Delivery of Cytotoxic Agents to Tumor Cells
(continued from page 1)

Upcoming Events

  • Experimental Biology / April 21-23, 2013 / Boston, MA / Booth #876
  • American Associaton of Immunologists / May 5-7, 2013 / Honolulu, HI / Booth #1638

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