Targeting Trends Newsletter 10q1

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Newsletter Highlights

  • 2009 SfN Poster Award Winner (page 2)
  • Lot-to-lot variation; Saporin activity (page 5)
  • Teaser Winners (page 4)
  • Leptin-SAP (page 7)
  • New Distributor (page 7)
  • Complete and Submit the Targeting Teaser online!

Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats – read article (continued on page 6)

Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter
Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA

Product information related to cover article: Leptin-SAP (Cat. #IT-47) and Blank-SAP (Cat. #IT-21)

2009 Society for Neuroscience Poster Award Winner

  • “Leptin-saporin injection into the arcuate nucleus lesions NPY/AGRP and POMC neurons and produces hyerphagia, obesity and changes in diurnal feeding patterns in rat.”
    Presented by A-J Li, Q.Wang, T.T. Dinh and Sue Ritter.  Featuring Leptin-SAP (Cat. #IT-47) and Blank-SAP (Cat. #IT-21)
  • Contender – “Introcerebroventricular injections of mu p75-saporin can produce memory deficits without impairing motor deficits in a mouse model of Alzheimer’s disease.”
    Presented by J.J Matchynski, S. Lowrance, J. Rossignol, N. Puckett, N. Derkorver, J.Radwan, K. Trainor, M. Sandstrom and G. Dunbar. Featuring mu p75-SAP (Cat. #IT-16)
  • Contender – “Immunotoxic lesion of hypothalamic noradrenergic/adrenergic input ameliorates the effects of peripheral LPS challenge on sickness behavior and associated brain c-Fos expression.”
    Presented by R.P. Gaykema, G.C. Thacker, N.J. Shapiro and L.E. Goehle.  Featuring anti-DBH-SAP (Cat. #IT-03)
  • More SFN abstracts.

Recent Scientific References (read online)

  • Wilson RE, Coons KD, Sengelaub DR (2009) Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats. Neurosci Lett 465:123-127. (Cat. #IT-14)
  • Riedl MS, Braun PD, Kitto KF, Roiko SA, Anderson LB, Honda CN, Fairbanks CA, Vulchanova L (2009) Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. J Neurosci 29:13377-13388. (Cat. #AB-N03)
  • Robertson RT, Baratta J, Yu J, LaFerla FM (2009) Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience 164:1334-1346. (Cat. #IT-01)
  • Marshall AM, Nommsen-Rivers LA, Hernandez LL, Dewey KG, Chantry CJ, Gregerson KA, Horseman ND (2009) Serotonin Transport and Metabolism in the Mammary Gland Modulates Secretory Activation and Involution. J Clin Endocrinol Metab [Epub Dec 4]. (Cat. #AB-N09)
  • Jinks SL, Carstens E, Antognini JF (2009) Nitrous oxide-induced analgesia does not influence nitrous oxide’s immobilizing requirements. Anesth Analg 109:1111-1116. (Cat. #IT-03; Cat. #IT-18)
  • Dashniani M, Burjanadze M, Beselia G, Maglakelidze G, Naneishvili T (2009) Spatial memory following selective cholinergic lesion of the nucleus basalis magnocellularis. Georgian Med News 77-81. (Cat. #IT-01; Cat. #IT-18)
  • Arias-Carrion O, Murillo-Rodriguez E (2009) Cell transplantation: a future therapy for narcolepsy? CNS Neurol Disord Drug Targets 8:309-314. (Cat. #IT-20)

Targeting Teaser Winners

The Importance of Product References

Targeting Talk (see text)

Upcoming Events

  • American Association for Cancer Research • April 17-21, 2010 • Washington, DC • Booth #2011
  • Forum of European Neuroscience – July 3-7, 2010 • Amsterdam, The Netherlands • Booth #507

Targeting Tools: Featured Products

Worldwide Distributors (see list)

Gangsta Gallery

Targeting Technology Tutorial

Targeting Teaser (Jumble)