Targeted Toxins
Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery.
The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized).
The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface.
The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death.
Cells that do not have the cell surface marker are not affected.
| Product | Target |
|---|---|
| 192-IgG-SAP (Cat. #IT-01) | cells that express p75NTR in rat |
| Acetylated LDL-SAP (Cat. #IT-08) | cells that express microglia in primary cell cultures |
| Anti-6 His-SAP (Cat. #IT-52) | cells with extracellular expression of 6 His-tagged proteins |
| Anti-CD103-SAP (Cat. #IT-50) | cells that express CD103 |
| Anti-CD105-SAP (Cat. #IT-80) | cells that express human CD105 (Endoglin) |
| Anti-CD117-SAP (Cat. #IT-83) | cells that express CD117 in mice |
| Anti-CD133-SAP (Cat. #IT-82) | cells that express CD133 in human |
| Anti-CD22-SAP human (Cat. #IT-37) | cells that possess the group-A epitope of the human B-cell antigen, CD22 in human |
| Anti-CD25-SAP human (Cat. #IT-24) | cells that express Interleukin-2 (IL-2) receptor in human |
| Anti-CD25-SAP mouse (Cat. #IT-29) | cells that express Interleukin-2 (IL-2) receptor in mouse |
| Anti-CD44-SAP (Cat. #IT-72) | cells that express all isoforms of the CD44 receptor in multiple species |
| Anti-CD45.2-SAP (Cat. #IT-91) | cells that express mouse CD45.2 in mouse |
| Anti-ChAT-SAP (Cat. #IT-42) | cells that express choline acetyltransferase in multiple species |
| Anti-DAT-SAP (Cat. #IT-25) | cells that express dopamine transporter (DAT-ECD) in rat or human |
| Anti-DBH-SAP (Cat. #IT-03) | cells that express dopamine beta-hydroxylase in rat |
| Anti-FLAG (M5)-SAP (Cat. #IT-59) | cells with extracellular expression of FLAG-tagged proteins |
| Anti-GFP-SAP (Cat. #IT-53) | cells with extracellular expression of GFP-tagged proteins |
| Anti-PD-L1-SAP (Cat. #IT-45) | cells that express human programmed death-ligand 1 (PD-L1) |
| Anti-SERT-SAP (Cat. #IT-23) | cells that express serotonin re-uptake transporter |
| Anti-V5-SAP (Cat. #IT-58) | cells with extracellular expression of V5-tagged proteins |
| Anti-vGAT-SAP (Cat. #IT-71) | cells that express express the vesicular GABA transporter |
| Anti-YFP-SAP (Cat. #IT-66) | cells with extracellular expression of YFP and EYFP-tagged proteins |
| Bombesin-SAP (Cat. #IT-40) | cells that express gastrin releasing peptide (GRP) receptor |
| CCK-SAP (Cat. #IT-31) | cells that express CCK Receptor |
| Chlorotoxin-SAP (Cat. #IT-86) | cells that express MMP-2 isoforms |
| CRF-SAP (Cat. #IT-13) | cells that express the corticotropin-releasing factor (hormone) receptor 1 |
| CTB-SAP (Cat. #IT-14) | cells that express the GM1 receptor |
| Dermorphin-SAP / MOR-SAP (Cat. #IT-12) | cells that express the mu-opioid receptor (MOR) |
| Dyno-SAP (Dynorphin-SAP) (Cat. #IT-68) | cells that express kappa-opioid receptor |
| Ex4-SAP (GLP-1-SAP) (Cat. #IT-90) | cells that express GLP-1R |
| FGF-SAP (Cat. #IT-38) | cells that express FGF receptor |
| Galanin-SAP (Cat. #IT-34) | cells that express galanin-1 receptor |
| GAT1-SAP (Cat. #IT-32) | cells that express GABA-1 transporter in mutiple species |
| Hemokinin 1-SAP (Cat. #IT-76) | cells that express neurokinin-1 (NK-1) receptor |
| IB4-SAP (Cat. #IT-10) | cells that express α-D-galactopyranoside residues |
| Leptin-SAP (Cat. #IT-47) | cells that express leptin receptor |
| Mac-1-SAP mouse/human (Cat. #IT-06) | cells that express Mac-1 (CD11b) receptor in mouse or human |
| ME20.4-SAP (Cat. #IT-15) | cells that express p75NTR in multiple species |
| Melanopsin-SAP (Cat. #IT-44) | cells that express melanopsin in mouse intrinsically photosensitive retinal ganglion cells |
| MOA-SAP (Cat. #IT-92) | cells that express specific galactose residues |
| mu p75-SAP (Cat. #IT-16) | cells that express p75NTR in mouse |
| Neurotensin-SAP (Cat. #IT-56) | cells that express neurotensin receptor |
| NKB-SAP (Cat. #IT-63) | cells that express NK3 (NKB receptor) |
| NMB-SAP (Cat. #IT-70) | cells that express Neuromedin B receptor |
| Nppb-SAP (Cat. #IT-69) | cells that express Neuropeptide natriuretic polypeptide b (Nppb or BNP) receptor |
| NPY-SAP (Cat. #IT-28) | cells that express the Neuropeptide Y (NPY) |
| Orexin-B-SAP (Cat. #IT-20) | cells that express the orexin-2 receptor |
| Oxytocin-SAP (Cat. #IT-46) | cells that express oxytocin receptor |
| PACAP-SAP (Cat. #IT-84) | cells that express VPAC1, VPAC2, or PAC1 receptors |
| SSP-SAP (Cat. #IT-11) | cells that express substance P receptor (NK-1) |
View a complete listing here.