Nppb-SAP [IT-69, KIT-69]

a tool for eliminating cells that express Neuropeptide natriuretic polypeptide b (Nppb or BNP) receptor; targeted via mouse BNP-32, eliminated via saporin

SKU: IT-69 Category: Host: mouse |Conjugate: streptavidin-saporin | Usage: eliminates cells |
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Itch is triggered by somatosensory neurons expressing the ion channel TRPV1 (transient receptor potential cation channel subfamily V member 1). Neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and research has found that Nppb lesioned mice selectively lose almost all behavioral responses to itch-inducing agents. Itch responses are blocked by toxin-mediated ablation of Nppb-receptor expressing cells, but a second neuropeptide, gastrin-releasing peptide (Bombesin-SAP, Cat #IT-40), still induces strong responses in the toxin-treated animals. Nppb-SAP eliminates cells expressing neuropeptide natriuretic polypeptide b (Nppb or BNP) receptor.

Nppb-SAP is a bonded toxin between mouse BNP-32 and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin. It eliminates Nppb-receptor expressing cells.

Nppb-SAP is available individually (Cat. #IT-69) or as a kit (Cat. #KIT-69) which includes Nppb-SAP, and Blank-Streptavidin-SAP (Cat. #IT-27B).