Galanin is a 29-amino acid peptide (30 amino acids in humans) implicated in a variety of functions including nociception, appetite, learning, and memory. It is widely distributed throughout the neural and endocrine systems, playing roles in the secretion of insulin, somatostatin, glucagon, dopamine, and growth hormone, and inhibiting the release of acetylcholine and substance P from myenteric neurons. Galanin-SAP eliminates cells expressing the galanin-1 receptor. It is not suitable for retrograde transport.
Galanin-SAP is a chemical conjugate of rat galanin and the ribosome-inactivating protein, saporin. It eliminates cells expressing the galanin-1 receptor.