Anti-DAT-SAP [IT-25]

a tool for eliminating cells that express dopamine transporter (DAT-ECD) in rat or human; targeted via a monoclonal antibody to the second extracellular loop of DAT, eliminated via saporin

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SKU: IT-25 Category: Product Size: 25 ug, 100 ug, 250 ug, 1 mg | Antibody Type: Monoclonal | Host: Rat | Reactivity: Human, rat | Conjugate: saporin | Usage: eliminates cells |

Description

The dopamine transporter (DAT) is a sodium-dependent reuptake carrier that is suspected to play a role in such neurologic and psychiatric disorders as Parkinson’s disease, Tourette’s syndrome, schizophrenia, and addiction. It is a 12-transmembrane domain transporter with the N- and C-terminus regions located within the cytoplasm. Because of its importance in dopamine use, DAT is an identifier of dopaminergic neurons.

Anti-DAT-SAP is highly specific for cells that express DAT, including mesencephalic dopamine neurons of the substantia nigra, pars compacta, and ventral tegmental area. Specific elimination of cells that express DAT is useful in studying the role of dopaminergic neurons in one of the devastating diseases of old age, Parkinson’s.

Anti-DAT-SAP is highly specific for cells that express DAT, including mesencephalic dopamine neurons of the substantia nigra, pars compacta, and ventral tegmental area.

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

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