CD11b is an alpha subunit of Mac-1, also known as CR3. Mac-1-SAP targets rat species using a monoclonal antibody targeting CR3 complement (C3bi) receptor expressed on macrophages, granulocytes, monocytes, NK cells, and dendritic cells. This antibody can recognize a shared common epitope between CD11b and CD11c. CD11b/c are involved in bacterial phagocytosis and are components of integrins, important for adhesion of neutrophils to surfaces. Mac-1-SAP is a potential tool for removing contaminating macrophages from primary cultures to determine their role(s) in autoimmune diseases and in degenerative disease such as Alzheimer’s.
Mac-1-SAP is a bonded toxin between a biotinylated rat monoclonal antibody to CD11b/c and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin.
Mac-1-SAP rat eliminates cells expressing rat CD11b/c. All other cells are left untouched.
Mac-1-SAP rat is available individually (Cat. #IT-105) or as a kit (Cat. #KIT-105) which includes Mac-1-SAP rat and BIgG-SAP Mouse (Cat. #IT-74).
keywords: Saporin, Mac-1, CD11b, CD11b/c, C3bi receptor, microglia, macrophages, CR3, alzheimer’s disease, AD