Anti-CD73 is a monoclonal antibody that specifically binds to CD73, a surface protein found on certain cancer cells, immune cells (like Tregs), and stromal cells. CD73 is often upregulated in tumors and the tumor microenvironment, especially in cancers like Glioblastoma, Melanoma, Triple-negative breast cancer and Ovarian and pancreatic cancers.
Anti-CD73-SAP is a chemical conjugate of the antibody to CD73 and the ribosome-inactivating protein, saporin.
Anti-CD73-SAP is available individually (Cat. #IT-101) or as a kit (Cat. #KIT-101) which includes Anti-CD73-SAP and Mouse IgG-SAP (Cat. #IT-18).
keywords: CD73, saporin, targeted toxin, cancer cells, immune cells, Tregs, stroma cells, Glioblastoma, Melanoma, Triple-negative breast cancer, Ovarian cancer, pancreatic cancer
Novel approaches towards cancer-directed immune checkpoint inhibition
Ploeg E (2023) Novel approaches towards cancer-directed immune checkpoint inhibition. Univ Groningen Thesis. doi: 10.33612/diss.737906343
Objective: To evaluate a novel bispecific antibody, bsAb CD73xEGFR, that inhibits the immunosuppressive enzyme CD73 on cancer cells in an EGFR-directed manner.
Summary: The researchers constructed a bispecific antibody, bsAb CD73xEGFR, that binds to both CD73 and EGFR on cancer cells. In preclinical studies, they found that bsAb CD73xEGFR was more effective than the monospecific anti-CD73 antibody oleclumab at reducing tumor growth and enhancing anti-tumor immune responses, likely due to its ability to direct CD73 inhibition specifically to cancer cells overexpressing EGFR.
Usage: Cancer cells were incubated with bsAb CD73xEGFR (1 μg/ml) (or controls) in the presence of Fab-ZAP human (Cat. #IT-51). Apoptotic cancer cell death was evaluated after 24 h by flow cytometry using Annexin-V/PI staining.
Related Products: Fab-ZAP human (Cat. #IT-51), Anti-CD73-SAP (Cat. #IT-101)
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