Targeted SAP conjugates are powerful and specific lesioning agents used in the technique known as Molecular Surgery. The ribosome-inactivating protein, saporin (from the seeds of the plant, Saponaria officinalis) is bound to a targeting agent (anything that is recognized on the cell surface and internalized). The targeted conjugate is administered to cells (in vitro or in vivo). The targeting agent seeks out and binds to its target on the cell surface. The conjugate is internalized, saporin breaks away from the targeting agent, and inactivates the ribosomes which causes protein inhibition and, ultimately, cell death. Cells that do not have the cell surface marker are not affected.
The noradrenaline transporter, also known as the norepinephrine trasnporter (NET), is responsible for the reuptake of norepinephrine. NET can also reuptake extracellular dopamine. NET is essential for regulating concentration in the synaptic cleft. Deficiency of NET is associated with orthostatic intolerance, an autonomic nervous system disorder, and an overabundance of NET is associated with ADHD. NET is also a target for psychostimulants such as cocaine and amphetamines, which disrupt the function of NET, consequently causing an increase of norepinephrine in synaptic clefts.
Anti-NET-SAP eliminates cells expressing the mouse noradrenaline transporter. All other cells are left untouched.
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.