The noradrenaline transporter, also known as the norepinephrine trasnporter (NET), is responsible for the reuptake of norepinephrine. NET can also reuptake extracellular dopamine. NET is essential for regulating concentration in the synaptic cleft. Deficiency of NET is associated with orthostatic intolerance, an autonomic nervous system disorder, and an overabundance of NET is associated with ADHD. NET is also a target for psychostimulants such as cocaine and amphetamines, which disrupt the function of NET, consequently causing an increase of norepinephrine in synaptic clefts.
Anti-NET-SAP eliminates cells expressing the mouse noradrenaline transporter. All other cells are left untouched.
The following control is recommended for validating the specificity of the beta conjugate: BIgG-SAP rabbit (Cat. #IT-75).
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.