Anti-Smoothened (SMO)-SAP [BETA-033]


a tool for eliminating cells that express the smoothened (SMO) receptor; targeted via biotinylated antibody to SMO and eliminated via saporin
This kit includes 25 ug Anti-Smoothened (SMO)-SAP Kit (BETA-033), 25 ug BIgG-SAP Rabbit (IT-75)

SKU: BETA-033 Category: Quantity: 25 ug | Antibody Type: affinity-purified, Polyclonal | Host: rabbit | Reactivity: human, mouse | Conjugate: streptavidin-saporin | Usage: eliminates cells, retrograde transport |

The smoothened (SMO) receptor, a signal transducer in the hedgehog/patched protein signaling pathway, is responsible for the maintenance of normal embryonic development and is implicated in carcinogenesis. It is classified as a class frizzled (class F) G-protein-coupled receptor (GPCR). Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. Use this new tool to study the therapeutic potential of Hedgehog (Hh) pathway inhibitors and Smoothened (SMO) antagonists as emerging anticancer therapies.

Anti-Smoothened (SMO)-SAP eliminates cells expressing the smoothened (SMO) receptor.

The following control is included for validating the specificity of the beta conjugate: BIgG-SAP rabbit (Cat. #IT-75).

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.

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