The melanocortin receptor 4 (MC4R) is a G-protein-coupled receptor that specifically binds melanocyte stimulating hormones (α, β, γ-MSH). Studies in murine models have shown these receptors to be involved in energy homeostasis, feeding behavior, sexual behavior, and male erectile function. With obesity in humans now also becoming such a problem, this receptor has become a topic of interest because of its involvement in related aspects such as insulin resistance, fat mass, weight and risk of obesity.
Anti-MC4R-SAP eliminates cells expressing human or rat MC4R.
The following control is recommended for validating the specificity of the beta conjugate: BIgG-SAP rabbit (Cat. #IT-75).
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.