Anti-Cripto-SAP [BETA-017]

$50.00

[anti-mouse/human Cripto-1]-saporin

SKU: BETA-017 Categories: , Product Size: 25 ug | Antibody Type: affinity-purified, Polyclonal | Host: Rabbit | Reactivity: Human, Mouse | Conjugate: saporin | Usage: eliminates cells |

Description

Cripto, also known as TDGF-1 (Teratocarcinoma-Derived Growth Factor), is the founding member of the Epidermal Growth Factor-Cripto-1/FRL1/Cryptic Protein family of signaling proteins that function in cancer and various developmental processes. Genetic evidence from mice and zebrafish points to a role for Cripto as an essential cofactor in Nodal signaling. In the Nodal signaling pathway of embryonic development, Cripto has been shown to have dual function as a co-receptor as well as ligand. Particularly in cell cultures, it has been shown to act as a signaling molecule with the capabilities of a growth factor, and in co-culture assays, it has displayed the property of a co-ligand toåÊNodal. Glycosylation is responsible for mediating this interface withåÊNodal. Cripto proteins‰Ûª composition as a receptor complex is further solidified by the GPI linkage, making the cell membrane connection able to regulate growth factor signaling of Nodal.

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.

Anti-Cripto-SAP eliminates cells expressing mouse/human Cripto (TDGF-1).

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.

View Data Sheet

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