Anti-Cripto-SAP [BETA-017]

25 ug

$50.00

[anti-mouse/human Cripto-1]-saporin

SKU: BETA-017 Categories: ,

Description

Cripto, also known as TDGF-1 (Teratocarcinoma-Derived Growth Factor), is the founding member of the Epidermal Growth Factor-Cripto-1/FRL1/Cryptic Protein family of signaling proteins that function in cancer and various developmental processes. Genetic evidence from mice and zebrafish points to a role for Cripto as an essential cofactor in Nodal signaling. In the Nodal signaling pathway of embryonic development, Cripto has been shown to have dual function as a co-receptor as well as ligand. Particularly in cell cultures, it has been shown to act as a signaling molecule with the capabilities of a growth factor, and in co-culture assays, it has displayed the property of a co-ligand to Nodal. Glycosylation is responsible for mediating this interface with Nodal. Cripto proteins’ composition as a receptor complex is further solidified by the GPI linkage, making the cell membrane connection able to regulate growth factor signaling of Nodal.

Anti-Cripto-SAP eliminates cells expressing mouse/human Cripto (TDGF-1).

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.

View Data Sheet

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