Key Features. Real Advantages.

Internalization data is only useful if you can trust what you’re seeing.

Because pHast Conjugates activate specifically in acidic intracellular compartments, they help distinguish internalized material from surface-bound signal and reduce the background that can complicate interpretation with traditional assays. The result is a clearer, more biologically relevant readout of internalization with less ambiguity and less assay complexity.

That cleaner signal also supports faster decision-making. By simplifying the workflow and reducing the need for extensive interpretation, pHast can help researchers screen candidates more efficiently and move forward with greater confidence.

Key Features. Real Advantages. True internalization: Activates only after internalization to ensure accurate detection of intracellular delivery. Low background: Minimizes surface signal for a clear, high-contrast readout with improved signal to noise. High specificity: Designed to reduce off-target activation for more reliable results. Fast results: Designed for rapid activation to deliver results quickly and keep your experiments moving. Bright signal: Delivers strong fluorescence upon activation for easy detection across multiple platforms. Versatile Formats: Fab-pHast and Stretavidin-pHast options to fit a wide range of targeting materials and research needs. Workflow ready: Simple to implement in existing workflows for seamless integration and reproducibility. Built for performance. Designed for discovery. Trusted for results.