NGFR Antibodies
ATS has 3 NGFR antibodies that work in different species
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AB-N01
AB-N01 also known as mu p75, and the affinity-purified version, AB-N01AP recognize the p75 receptor in mouse
AB-N07
AB-N07 also known as ME20.4, recognizes the p75 receptor in human, cat, dog, pig, primate, and sheep
AB-N43
AB-N43 also known as 192-IgG, recognizes the p75 receptor in rat
Each of these antibodies can be used in the following in vitro applications
- Flow cytometry
- Immunolabeling
- Immunoprecipitation
- Western blot
The NGFR antibodies can be used for immunolabeling. For example, here you can see data from Human Induced Pluripotent Stem Cells stained to show p75 receptor expression in these cells.
Each of the NGFR antibodies is also available
as a targeting agent attached to Saporin
Each immunotoxin will eliminate cells that express the p75 receptor. This specific neuronal depletion is frequently used in behavior research and in animal models of dementia.
When ATS conjugates an NGFR antibody to the ribosome-inactivating protein, saporin, an immunotoxin is created. This immunotoxin can be used in vivo to specifically bind to cells that express the p75 receptor on the cell surface.
Once internalized, saporin inactivates the ribosomes, which shuts down protein synthesis and causes cell death.
Only cells that express the p75 receptor will be affected. There is no off-target cell damage.