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Nicotinamide mononucleotide adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure.
Pottorf T, Mann A, Fross S, Mansel C, Vohra BPS (2018) Nicotinamide mononucleotide adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure. Neurochem Int 121:86-97. doi: 10.1016/j.neuint.2018.09.010 PMID: 30278188
Objective: To Investigate the link between NMNAT2 loss, Golgi fragmentation and axon degeneration
Summary: Results degeneration signals converge on a common cytNmnat1 mediated axon protective program and are distinct from the SARM1 mediated caspase independent axon degeneration
Usage: Immunohistochemistry (1:1000)
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats
Andrews JL, Newell KA, Matosin N, Huang XF, Fernandez F (2018) Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats. Neuronal Signal 2(3):NS20180059. doi: 10.1042/NS20180059 PMID: 32714588
Objective: To investigate the effects of perinatal phencyclidine (PCP) administration on levels of expression of Lingo-1 signaling proteins in the prefrontal cortex, a critical region for cognitive processing that is consistently reported to be disrupted in schizophrenia.
Summary: Study showed alterations in Lingo-1 signaling pathway proteins in the prefrontal cortex of rats from a neurodevelopmental PCP model of schizophrenia.
Usage: protein expression
Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity.
Virga DM, Capps J, Vohra BPS (2018) Enteric neurodegeneration is mediated through independent neuritic and somal mechanisms in rotenone and MPP+ toxicity. Neurochem Res 43(12):2288-2303. doi: 10.1007/s11064-018-2649-x PMID: 30259276
Objective: To investigate the mechanism by which enteric nervous system degeneration occurs in Parkinson’s Disease.
Summary: Therapies targeting both axonal and somal protection can be important in finding interventions for enteric symptoms in PD.
Usage: P75NTR antibody utilized (1:1000) to immunoselect enteric neural crest from the rest of the cells in the gut including stomach, small and large bowl and colon) from E12.5 Sprague CD1 mice.
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Molecular diversity of intrinsically photosensitive ganglion cells
Berg D, Kartheiser K, Leyrer M, Saali A, Berson D (2018) Molecular diversity of intrinsically photosensitive ganglion cells. bioRxiv 381004. doi: 10.1101/381004
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)
Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line
Yang WH, Cheng CY, Chen MF, Wang TC (2018) Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line. 38(9):5183-5192. doi: 10.21873/anticanres.12841 PMID: 30194166
Objective: This study is focused on the possible role of p75NTR in glioma tumor initiation.
Summary: Cells with p75NTR overexpression demonstrated certain unique characteristics of tumor-initiating cells, such as neurosphere formation, high colony proliferation, and resistance to radio- and chemotherapy. With regard to the heterogeneous composition of glioma cells, p75NTR can be used as an alternative marker to identify a glioma subpopulation with tumor-initiating properties.
Usage: flow cytometry
Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus
Micakovic T, Papagiannarou S, Clark E, Kuzay Y, Abramovic K, Peters J, Sticht C, Volk N, Fleming T, Nawroth P, Hammes HP, Alenina N, Grone HJ, Hoffmann SC (2018) The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus. Kidney Int 94:937-950. doi: 10.1016/j.kint.2018.06.006 PMID: 30190172
Objective: To investigate the role of the angiotensin II type 2 receptor (AT-2R) at the early stages of diabetic nephropathy.
Summary: Targeted AT-2R overexpression in renal cells may open new avenues to develop novel types of drugs preventing diabetic nephropathy.
Usage: Histology, immunohistochemistry; 1:100
Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons
Donnelly CR, Gabreski NA, Suh EB, Chowdhury M, Pierchala BA (2018) Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. J Cell Biol 217:327. doi: 10.1083/jcb.201703120 PMID: 30018091
Summary: The authors investigated the interactions of pro-survival and pro-apoptotic receptors in Programmed Cell Death (PCD) using the sympathetic nervous system as a model. They demonstrate that Ret, a receptor tyrosine kinase required for the survival of many neuronal populations, is restricted to a subset of degenerating neurons that rapidly undergo apoptosis.
Usage: Proximity ligation assays (1:500); Western blotting (1:1,000)
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy.
Zhang Z, Jiang SM, Ma YP, Dai PL, Wang YN, Zou GM, Gao HM, Yang Y, Li WG (2019) Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy. Mol Cell Biochem 453:103-110. doi: 10.1007/s11010-018-3435-4 PMID: 30159797
Objective: To investigate the role of intrarenal renin-angiotensin system (RAS) in the development of human kidney disease. Patients with IgA nephropathy (IgAN) were screened and their clinical characteristics analyzed.
Summary: Overexpression of AT1R on the mesangial cells of IgAN patients is associated with mesangial cell proliferation, glomerular segmental sclerosis, and crescent formation.
Usage: immunohistochemistry (1:500)
Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)
Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina
Jo A, Xu J, Deniz S, Cherian S, DeVries SH, Zhu Y (2018) Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina. Front Neural Circuits 12:66. doi: 10.3389/fncir.2018.00066 PMID: 30186122
Objective: To obtain unambiguous information about retinal processing.
Summary: Results establish a foundation for future application of intersectional strategies in the retina and retino-recipient regions.
Usage: Immunohistochemistry 1:1000.
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)
In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons
Tao X, Li N, Liu F, Hu Y, Liu J, Zhang Y-M (2018) In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons. Heliyon 4:e00730. doi: 10.1016/j.heliyon.2018.e00730 PMID: 30148218
Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)