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Inhibition of methamphetamine self-administration and reinstatement by central blockade of angiotensin II receptor in rats.
Xu X, Pan J, Li X, Cui Y, Mao Z, Wu B, Xu H, Zhou W, Liu Y (2019) Inhibition of methamphetamine self-administration and reinstatement by central blockade of angiotensin II receptor in rats. J Pharmacol Exp Ther 369(2):244-258. doi: 10.1124/jpet.118.255729 PMID: 30867225
Objective: To explore the role of central angiotensin II receptor (ATR) in drug taking and seeking behavior associated with methamphetamine (METH) use disorder.
Summary: The AT1R-PLCβ-CREB signaling pathway was found to be associated with the effect of AT1R on the drug-taking and drug-seeking behavior involving METH use disorder.
Usage: Membranes were incubated at 4°C overnight (1:1000). Western blot.
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism.
Matamoros AJ, Tom VJ, Wu D, Rao Y, Sharp DJ, Baas PW (2019) Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism. J Neurosci 39(11):2011-2024. doi: 10.1523/JNEUROSCI.1888-18.2018 PMID: 30647150
Objective: To test whether fidgetin knockdown assists axonal regeneration.
Summary: Results show that DRG neurons in which fidgetin was knocked down displayed enhanced regeneration of axons across the dorsal root entry zone into the spinal cord. The results establish fidgetin as a novel therapeutic target to augment nerve regeneration.
Usage: immunohistochemistry
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Palladium based nanoparticles for the treatment of advanced melanoma.
Elsey J, Bubley JA, Zhu L, Rao S, Sasaki M, Pollack BP, Yang L, Arbiser JL (2019) Palladium based nanoparticles for the treatment of advanced melanoma. Sci Rep 9:3255. doi: 10.1038/s41598-019-40258-6 PMID: 30824801
Usage: immunohistochemistry (1:300)
Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)
Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model.
Katri A, Dąbrowska A, Löfvall H, Ding M, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K (2019) Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model. Arthritis Res Ther 21(1):68. doi: 10.1186/s13075-019-1819-9 PMID: 30795801
Objective: To investigate if combining a standard of care NSAID (naproxen) with a Key Bioscience peptides (KBP) resulted in improvement in pain scores, as well as disease activity and structural damage in a rat model of rheumatoid arthritis (RA).
Summary: Combination therapy had improved efficacy over naproxen monotherapy; combination therapy resulted in improved health scores, and reduced mechanical and cold allodynia assessment. Furthermore, protection of articular cartilage structure and preservation of bone structure and bone volume were also observed.
Usage: histology (1:4000)
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Degeneration of ipRGCs in mouse models of huntington’s disease disrupts non-image-forming behaviors before motor impairment.
Lin M-S, Liao P-Y, Chen H-M, Chang C-P, Chen S-K, Chern Y (2019) Degeneration of ipRGCs in mouse models of huntington’s disease disrupts non-image-forming behaviors before motor impairment. J Neurosci 39(8):1505. doi: 10.1523/JNEUROSCI.0571-18.2018 PMID: 30587542
Summary: Results show that M1 ipRGCs were susceptible to the toxicity caused by mutant Huntingtin. The resultant impairment of M1 ipRGCs contributed to the early degeneration of the ipRGC–SCN pathway and disrupted circadian regulation during HD progression.
Usage: Immunostaining (1:3000)
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)
Ro41-5253, a selective antagonist of retinoic acid receptor α, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits.
Ke Q, Li R, Cai L, Wu SD, Li CM (2019) Ro41-5253, a selective antagonist of retinoic acid receptor α, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits. Brain Res Bull 146:302-309. doi: 10.1016/j.brainresbull.2019.01.022 PMID: 30711623
Usage: histology
Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)
Brain-derived neurotrophic factor precursor in the hippocampus regulates both depressive and anxiety-like behaviors in rats.
Zhong F, Liu L, Wei J-L, Hu Z-L, Li L, Wang S, Xu J-M, Zhou X-F, Li C-Q, Yang Z-Y, Dai R-P (2019) Brain-derived neurotrophic factor precursor in the hippocampus regulates both depressive and anxiety-like behaviors in rats. Front Psychiatry 9:776. doi: 10.3389/fpsyt.2018.00776 PMID: 30740068
Objective: To investigate the role of proBDNF in the hippocampus in the development of depression and anxiety.
Summary: Despite some behavioral and morphological differences between depression and anxiety, hippocampal proBDNF is a common mediator to regulate these two mental disorders.
Usage: Western Blot
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots.
Ortgies DH, García-Villalón ÁL, Granado M, Amor S, Rodríguez EM, Santos HDA, Yao J, Rubio-Retama J, Jaque D (2019) Infrared fluorescence imaging of infarcted hearts with Ag2S nanodots. Nano Res 12:749–757. doi: 10.1007/s12274-019-2280-4 PMID: 0
Objective: To investigate the potential application of functionalized Ag2S nanodots for accurate imaging of damaged myocardium tissues after a myocardial infarction induced by either partial or global ischemia.
Summary: NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an indirect evaluation of the damage level.
Usage: Assessment of AT1R protein content in ischemic and non-ischemic hearts by Western blot (1:1000).
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)
Effects of Shugan Hewei Granule on depressive behavior and protein expression related to visceral sensitivity in a rat model of nonerosive reflux disease.
Wang Y, Li G, Wang X, Zhu S (2019) Effects of Shugan Hewei Granule on depressive behavior and protein expression related to visceral sensitivity in a rat model of nonerosive reflux disease. Evid Based Complement Alternat Med 2019:1505693. doi: 10.1155/2019/1505693 PMID: 30719054
Usage: immunofluorescent staining (1:200)
Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)
Expression of transcription factors divides retinal ganglion cells into distinct classes.
Sweeney NT, James KN, Nistorica A, Lorig-Roach RM, Feldheim DA (2019) Expression of transcription factors divides retinal ganglion cells into distinct classes. J Comp Neurol 527(1):225-235. doi: 10.1002/cne.24172 PMID: 28078709
Usage: Melanopsin (Opn4) Immunostaining 1:1000
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)