antibodies

Wang Z, Wu J-L, Zhong F, Liu Y, Yu Y-Q, Sun J-J, Wang S, Li H, Zhou X-F, Hu Z-L, Dai R-P (2019) Upregulation of proBDNF in the mesenteric lymph nodes in septic mice. Neurotox Res 36(3):540-550. doi: 10.1007/s12640-019-00081-3 PMID: 31278527

Objective: To characterize the expression pattern of proBDNF in mesenteric lymph nodes (MLNs) after lipopolysaccharide (LPS) stimulation, and to investigate the association of pathogenesis of sepsis.

Summary: This study provided direct evidence that sepsis promoted the proliferation of CD3+, CD4+, and CD8+ T cells, but inhibits CD19+ B cells in the MLNs. Also, proBDNF was upregulated during the sepsis, which was mainly localized on CD3+ and CD4+ T cells in MLNs. The upregulation of proBDNF signaling and cytokines activation in the MLNs may be involved in the disease progress of sepsis.

Usage: western blot (1:2000)

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Xu T, Zhou Z, Liu N, Deng C, Huang G, Zhou F, Liu X, Wang X (2019) Disrupted compensatory response mediated by Wolfram syndrome 1 protein and corticotrophin-releasing hormone family peptides in early-onset intrahepatic cholestasis pregnancy. Placenta 83:63-71. doi: 10.1016/j.placenta.2019.06.378 PMID: 31477210

Usage: Western (1:1000)

Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)

Beitia M, Solano-Iturri JD, Errarte P, Sanz B, Perez I, Etxezarraga MC, Loizate A, Asumendi A, Larrinaga G (2019) Altered expression of renin-angiotensin system receptors throughout colorectal adenoma-adenocarcinoma sequence. Int J Med Sci 16(6):813-821. doi: 10.7150/ijms.32599 PMID: 31337954

Usage: immunohistochemistry (1:100)

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Boakye PA, Rancic V, Whitlock KH, Simmons D, Longo FM, Ballanyi K, Smith PA (2019) Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor 1. J Neurophysiol 121(6):2308-2322. doi: 10.1152/jn.00839.2018 PMID: 30995156

Objective: To find missing steps in understanding how peripheral injury instigates central sensitization and the onset of neuropathic pain.

Summary: Colony-stimulating factor 1 (CSF-1) increases excitatory drive to excitatory neurons via a BDNF-dependent mechanism and decreases excitatory drive to inhibitory neurons via BDNF-independent processes.

Usage: immunohistochemistry (1:500)

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Soares DdS, Pinto GH, Lopes A, Caetano DSL, Nascimento TG, Andrades ME, Clausell N, Rohde LEP, Leitão SAT, Biolo A (2019) Cardiac hypertrophy in mice submitted to a swimming protocol: Influence of training volume and intensity on myocardial renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 316(6):R776-R782. doi: 10.1152/ajpregu.00205.2018 PMID: 31042418

Objective: To analyze the cardiac hypertrophy phenotype and the classical and alternative RAS axes in the myocardium of mice submitted to swimming exercises of varying volume and intensity for the development of cardiac hypertrophy.

Summary: Increasing exercise volume and intensity did not induce a pathological hypertrophy phenotype, but instead improved the oxidative capacity, and this process might have the participation of the RAS alternative axis.

Usage: Incubation at 4°C with anti-AT1R diluted in TTBS buffer with 5% non-fat 220 milk 1:800).

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

de Miguel E, Vekovischeva O, Elsilä LV, Panhelainen A, Kankuri E, Aitta-aho T, Korpi ER (2019) Conditioned aversion and neuroplasticity induced by a superagonist of extrasynaptic gabaa receptors: Correlation with activation of the oval BNST neurons and CRF mechanisms. Front Mol Neurosci 12:130. doi: 10.3389/fnmol.2019.00130 PMID: 31178693

Usage: immunohistochemistry (1:250)

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Xu Z, Zou C, Yu W, Xu S, Huang L, Khan Z, Wang J, Liang G, Wang Y (2019) Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction. Br J Pharmacol 176(14):2627-2641. doi: 10.1111/bph.14686 PMID: 30958891

Objective: To investigate the underlying mechanisms of STAT3 activation by angiotensin II and downstream functional consequences in the kidneys.

Summary: This study reveals a novel mechanism of STAT3 activation, induced by angiotensin II, in kidney tissues and highlights a translational significance of a STAT3 inhibitor as potential therapeutic agent for hypertensive kidney disease.

Usage: Western blot

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Alarautalahti V, Ragauskas S, Hakkarainen JJ, Uusitalo-Järvinen H, Uusitalo H, Hyttinen J, Kalesnykas G, Nymark S (2019) Viability of mouse retinal explant cultures assessed by preservation of functionality and morphology. Invest Ophthalmol Vis Sci 60(6):1914-1927. doi: 10.1167/iovs.18-25156 PMID: 31042799

Summary: Organotypic retinal explant cultures have been used to study retinal development, retinal diseases and injuries, drug screening, and retinal stem cell therapies.

Usage: The amount of ganglion cells and melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) were detected by staining of RNA-binding protein. Melanopsin detection by immunostaining. 1:2500

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Kim E, Hwang S-H, Kim H-K, Abdi S, Kim HK (2019) Losartan, an angiotensin II type 1 receptor antagonist, alleviates mechanical hyperalgesia in a rat model of chemotherapy-induced neuropathic pain by inhibiting inflammatory cytokines in the dorsal root ganglia. Mol Neurobiol 56(11):7408-7419. doi: 10.1007/s12035-019-1616-0 PMID: 31037647

Objective: To assess losartan’s analgesic effect on paclitaxel-induced neuropathic pain (PINP) in rats and its mechanism of action in dorsal root ganglion (DRG).

Summary: The mechanical thresholds, protein levels of inflammatory cytokines, and cellular location of AT1R and interleukin 1β (IL-1β) in the DRG were assessed with behavioral testing, Western blotting, and immunohistochemistry, respectively.

Usage: western blot (1:100)

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Manavella DD, Cacciottola L, Payen VL, Amorim CA, Donnez J, Dolmans MM (2019) Adipose tissue-derived stem cells boost vascularization in grafted ovarian tissue by growth factor secretion and differentiation into endothelial cell lineages. Mol Hum Reprod 25(4):184-193. doi: 10.1093/molehr/gaz008 PMID: 30824937

Usage: immunohistochemistry (1:2000)

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