antibodies

Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ (2019) Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. J Biol Chem 294(31):11654-11664. doi: 10.1074/jbc.RA119.009045 PMID: 31213526

Usage: Western blot

Related Products: Tri-methyl Lysine Rabbit Polyclonal (Cat. #AB-265)

Suwannasual U, Lucero J, Davis G, McDonald JD, Lund AK (2019) Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Toxicol Sci 170(2):525-535. doi: 10.1093/toxsci/kfz121 PMID: 31132127

Objective: To investigate the hypothesis that inhalation exposure to a mixture of gasoline and diesel vehicle engine emissions (MVE) results in altered central nervous system microvascular integrity mediated by Ang II-AT1 signaling.

Summary: Inhalation exposure to traffic-generated pollutants results in altered BBB integrity, mediated through Ang II-AT1 signaling and inflammation, which is exacerbated by a high-fat diet.

Usage: Antibody was used in immunofluorescent staining of cerebral tissue. Brain sections (10 mm) were prepared for AT1 receptor (1:1000).

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Fu R, Han C-F, Ni T, Di L, Liu L-J, Lv W-C, Bi Y-R, Jiang N, He Y, Li H-M, Wang S, Xie H, Chen B-A, Wang X-S, Weiss SJ, Lu T, Guo Q-L, Wu Z-Q (2019) A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours. Nat Commun 10(1):3210. doi: 10.1038/s41467-019-11278-7 PMID: 31324807

Usage: immunohistochemistry (1:100)

Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)

Wu SJ, Coarfa C, Abbas H, Checker R, Dhar S, Rajapakshe K, Lee MG, Flores ER (2019) ∆Np63 executes an oncogenic program through the regulation of a common landscape of super-enhancer associated genes in non-small cell lung cancer. Cell Reports 3420369. doi: 10.2139/ssrn.3420369

Objective: To investigate how ΔNp63 serves to maintain lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) through the regulation and maintenance of lung stem cells that are necessary for lung adenocarcinoma and squamous cell initiation and progression.

Summary: ∆Np63 maintains lung ADC and SCC by keeping lung stem cells in quiescence. ChIP-seq analysis of lung basal cells and alveolar type 2 (AT2) cells lacking ∆Np63 revealed a robust loss of activating histone marks at super enhancers of cell identity genes defining a unifying oncogenic role for ∆Np63 in non-small cell lung cancer.

Usage: staining

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Verweij J, Chaney SY, Bredl D, Vemaraju S, König GM, Kostenis E, Lang RA, Copenhagen DR (2019) Light responses of melanopsin-expressing ganglion cells in the foetal mammalian retina. bioRxiv 675702. doi: 10.1101/675702

Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)

Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N (2019) Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats. Brain Res Bull 152:107-116. doi: 10.1016/j.brainresbull.2019.07.007 PMID: 31301380

Objective: To determine whether the respiratory center in the medulla functions normally in Pax6 mutant rats.

Summary: The Pax6 gene is involved in the functional development of the medullary respiratory center.

Usage: Anti-NK1r was used in immunofluorescence (1:800).

Related Products: NK-1 Receptor Rabbit Polyclonal, affinity-purified (Cat. #AB-N33AP)

Chen P, Huang Y, Wang Y, Li S, Chu H, Rong M (2019) MALAT1 overexpression promotes the proliferation of human periodontal ligament stem cells by upregulating fibroblast growth factor 2. Exp Ther Med 18(3):1627-1632. doi: 10.3892/etm.2019.7748 PMID: 31410118

Usage: western (1:1300)

Related Products: Fibroblast Growth Factor Rabbit Polyclonal, mammalian (Cat. #AB-07)

Wang Z, Wu J-L, Zhong F, Liu Y, Yu Y-Q, Sun J-J, Wang S, Li H, Zhou X-F, Hu Z-L, Dai R-P (2019) Upregulation of proBDNF in the mesenteric lymph nodes in septic mice. Neurotox Res 36(3):540-550. doi: 10.1007/s12640-019-00081-3 PMID: 31278527

Objective: To characterize the expression pattern of proBDNF in mesenteric lymph nodes (MLNs) after lipopolysaccharide (LPS) stimulation, and to investigate the association of pathogenesis of sepsis.

Summary: This study provided direct evidence that sepsis promoted the proliferation of CD3+, CD4+, and CD8+ T cells, but inhibits CD19+ B cells in the MLNs. Also, proBDNF was upregulated during the sepsis, which was mainly localized on CD3+ and CD4+ T cells in MLNs. The upregulation of proBDNF signaling and cytokines activation in the MLNs may be involved in the disease progress of sepsis.

Usage: western blot (1:2000)

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Xu T, Zhou Z, Liu N, Deng C, Huang G, Zhou F, Liu X, Wang X (2019) Disrupted compensatory response mediated by Wolfram syndrome 1 protein and corticotrophin-releasing hormone family peptides in early-onset intrahepatic cholestasis pregnancy. Placenta 83:63-71. doi: 10.1016/j.placenta.2019.06.378 PMID: 31477210

Usage: Western (1:1000)

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Beitia M, Solano-Iturri JD, Errarte P, Sanz B, Perez I, Etxezarraga MC, Loizate A, Asumendi A, Larrinaga G (2019) Altered expression of renin-angiotensin system receptors throughout colorectal adenoma-adenocarcinoma sequence. Int J Med Sci 16(6):813-821. doi: 10.7150/ijms.32599 PMID: 31337954

Usage: immunohistochemistry (1:100)

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)