Angiotensin II receptor

Ma YP, Yang Y, Jiang SM, Liu L, Zhang Z, Wang YN, Zou GM, Li WG (2020) Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy. J Renin Angiotensin Aldosterone Syst 21(2):1470320320919607. doi: 10.1177/1470320320919607 PMID: 32370637

Objective: To assess the renal expression of angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and MAS receptor in human type 2 diabetic nephropathy (DN).

Summary: Renal expression levels of AT1R increase during the early stages of DN, ARB reducing AT1R while increasing MAS receptor. Therefore, ARB should be used as soon as possible in patients with DN.

Usage: Immunohistochemistry

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Zhou G, Li J, Zeng T, Yang P, Li A (2020) The regulation effect of WNT-RAS signaling in hypothalamic paraventricular nucleus on renal fibrosis. J Nephrol 33(2):289-297. doi: 10.1007/s40620-019-00637-8 PMID: 31392659

Objective: To investigate whether abnormal expression of central wnt/β-catenin signaling and renin-angiotensin system (WNT-RAS signaling) was tightly involved in chronic kidney disease (CKD).

Summary: These data suggest that the central WNT-RAS signaling plays a significant role in the development and progression of CKD.

Usage: immunohistochemistry and western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Li S, Zhao W, Tao Y, Liu C (2020) Fugan Wan alleviates hepatic fibrosis by inhibiting ACE/Ang II/AT-1R signaling pathway and enhancing ACE2/Ang 1-7/Mas signaling pathway in hepatic fibrosis rat models. Am J Transl Res 12(2):592-601. PMID: 32194907

Objective: To investigate protective effects of Fugan Wan (FGW) on hepatic fibrosis and clarify associated mechanisms.

Summary: FGW alleviated hepatic fibrosis by inhibiting ACE/Ang II/AT-1R signaling and enhancing ACE2/Ang 1-7/Mas signaling pathway in hepatic fibrosis rat models.

Usage: Western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Abbasloo E, Najafipour H, Vakili A (2020) Chronic treatment with apelin, losartan and their combination reduces myocardial infarct size and improves cardiac mechanical function. Clin Exp Pharmacol Physiol 47:393-402. doi: 10.1111/1440-1681.13195 PMID: 31630435

Objective: To determine the effect of chronic pretreatment with apelin, losartan and their combination on ischemia-reperfusion (IR) injury in the isolated perfused rat heart and on the expression of apelin-13 receptor (APJ) and angiotensin type 1 receptor (AT1R) in the myocardium.

Summary: Chronic pretreatment with apelin along with AT1R antagonist had more protective effects against IR injury.

Usage: 1:10000

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Aoyagi Y, Furuyama T, Inoue K, Matsuda D, Matsubara Y, Okahara A, Ago T, Nakashima Y, Mori M, Matsumoto T (2019) Attenuation of angiotensin II–induced hypertension in BubR1 low‐expression mice via repression of angiotensin II receptor 1 overexpression. J Am Heart Assoc 8(23):e011911. doi: 10.1161/JAHA.118.011911 PMID: 31787052

Usage: western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Lu W, Wang Q, Sun X, He H, Wang Q, Wu Y, Liu Y, Wang Y, Li C (2019) Qishen Granule improved cardiac remodeling via balancing M1 and M2 macrophages. Front Pharmacol 10:1399. doi: 10.3389/fphar.2019.01399 PMID: 31824322

Objective: To explore the effect of Qishen Granule (QSG) on the release of splenic monocytes, the recruitment of monocytes into heart tissues and the differentiation of macrophages under ischemic conditions.

Summary: Compounds of Chinese medicine have synergistic effects on cardiac and splenic organs through regulating differentiation of monocytes/macrophages in inhibiting myocardial remodeling.

Usage: Western blot

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Abd El‐Rahman SS, Fayed HM (2019) Targeting AngII/AT1R signaling pathway by perindopril inhibits ongoing liver fibrosis in rat. J Tissue Eng Regen Med 13:2131-2141. doi: 10.1002/term.2940 PMID: 31348596

Usage: IHC (1:100)

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Martins JR, Reichhart N, Kociok N, Stindl J, Foeckler R, Lachmann P, Todorov V, Castrop H, Strauß O (2019) Systemic ß adrenergic stimulation/ sympathetic nerve system stimulation influences intraocular RAS through cAMP in the RPE. Exp Eye Res 189:107828. doi: 10.1016/j.exer.2019.107828 PMID: 31589840

Objective: To investigate whether systemic β-adrenergic stimulation of the retinal pigment epithelium (RPE) also modulates renin expression in the RPE.

Summary: In vitro analysis of renin gene expression using polarized porcine RPE showed that the activity of the renin promoter can be increased by cAMP stimulation (IBMX/forskolin) but was not influenced by angiotensin-2.

Usage: Immunohistochemistry; eye sections were labeled overnight at 4°C with Anti-AT-1R.

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Zhuo X, Wu Y, Yang Y, Gao L, Qiao X, Chen T (2019) LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPARγ. Life Sci 233:116745. doi: 10.1016/j.lfs.2019.116745 PMID: 31404524

Objective: To find the functional lncRNAs associated with hypertension, high throughput lncRNA microarray were used to analyze expression profile of the lncRNAs in the aortic vascular endothelial cells of spontaneously hypertensive rats.

Summary: lncRNA AK094457 is identified as a key regulator in blood pressure and endothelial function, which can increase AngII-induced hypertension and endothelial dysfunction via suppression of PPARγ.

Usage: Western Blot (1:500), immunohistochemistry

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Suwannasual U, Lucero J, Davis G, McDonald JD, Lund AK (2019) Mixed vehicle emissions induces angiotensin ii and cerebral microvascular angiotensin receptor expression in C57Bl/6 mice and promotes alterations in integrity in a blood-brain barrier coculture model. Toxicol Sci 170(2):525-535. doi: 10.1093/toxsci/kfz121 PMID: 31132127

Objective: To investigate the hypothesis that inhalation exposure to a mixture of gasoline and diesel vehicle engine emissions (MVE) results in altered central nervous system microvascular integrity mediated by Ang II-AT1 signaling.

Summary: Inhalation exposure to traffic-generated pollutants results in altered BBB integrity, mediated through Ang II-AT1 signaling and inflammation, which is exacerbated by a high-fat diet.

Usage: Antibody was used in immunofluorescent staining of cerebral tissue. Brain sections (10 mm) were prepared for AT1 receptor (1:1000).

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)