Ogawa T, Li Y, Lua I, Hartner A, Asahina K (2018) Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers. 247(6):867-881. doi: 10.1002/dvdy.24634 PMID: 29665133

Objective: The aim of this study is to identify specific markers for embryonic Hepatic stellate cells (HSCs).

Summary: ITGA8 is a specific cell surface marker of MC-derived HSCs and perivascular mesenchymal cells in the developing liver. Our data suggest that ITGA8+ mesenchymal cells maintain the phenotype of hepatoblast in liver development.

Usage: Immunofluorescence (1:1000)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Xu K, Pan X, Qiu X, Wang D, Dong N, Yang L, Li S (2018) Neural crest-derived cells migrate from nerve to participate in Achilles tendon remodeling. Wound Repair Regen 26(1):54-63. doi: 10.1111/wrr.12614 PMID: 29381243

Objective: To investigate the role of neural crest (NC)-derived cells in tendon regeneration.

Summary: It is concluded that after Achilles tendon injury, nerves sprout into the wound site. The NC-derived Vmt1/FAP1 mesenchymal cells and peripheral nerves participate in tendon regeneration.

Usage: Histological immunofluorescence and immunostaining

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K (2018) The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. J Neurosci 38:2589-2604. doi: 10.1523/JNEUROSCI.0953-17.2018. PMID: 29440387

Objective: To investigate whether the soluble form of LOTUS (s-LOTUS) also has an inhibitory action on NgR1 function as a candidate for therapeutic agents

Summary: Findings suggest that s-LOTUS inhibits NgR1-mediated signaling possibly by interfering with the interaction between NgR1 and p75NTR. Thus, s-LOTUS may have potential as a therapeutic agent for neuronal regeneration in the damaged CNS

Usage: staining (1:1000)

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Sparks NRL, Martinez IKC, Soto CH, Zur Nieden NA-O (2018) Low osteogenic yield in human pluripotent stem cells associates with differential neural crest promoter methylation. Stem Cells 36:349-362. doi: 10.1002/stem.2746 PMID: 29193426

Objective: To compare the osteogenic potential of two human induced pluripotent stem cell lines (RIV9 and RIV4) to human H9 embryonic stem cells.

Summary: The study demonstrates that different hPSC lines, including individual hiPSC clones, could have inherently different abilities to produce functional osteoblasts potentially based on the methylation marks placed on promotor regions important for lineage decisions

Usage: immunohistochemistry

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Jones I, Novikova LN, Novikov LN, Renardy M, Ullrich A, Wiberg M, Carlsson L, Kingham PJ (2018) Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury. J Tissue Eng Regen Med 12(4):e2099-e2109. doi: 10.1002/term.2642 PMID: 29327452

Objective: To determine if differentiated neural crest cells are promising supporting cell candidates to aid in peripheral nerve repair.

Summary: In this study, neural crest cells were differentiated from human embryonic stem cells. NGFR (mouse monoclonal, 1:100) Immunocytochemistry. The specificity of NGFR antibody was validated by immunocytochemical staining of both hESCs- and MACS-enriched cells.

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Liu W, Zhao Y, Zhang X, Ji J (2018) Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia. Mol Med Rep 17(1):1885-1892. doi: 10.3892/mmr.2017.8098 PMID: 29257256

Objective: To investigate a potential mechanism underlying simvastatin activity in hippocampal cells.

Summary: The preclinical results indicate that simvastatin is efficient in preventing memory lapse and inhibiting apoptosis of hippocampal cells via the ERK/AKT signaling pathway, which may in the future improve cognitive decline and dementia in patients.

Usage: immunohistochemistry (1:500)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Brick RM, Sun AX, Tuan RSA-Ohoo (2018) Neurotrophically induced mesenchymal progenitor cells derived from induced pluripotent stem cells enhance neuritogenesis via neurotrophin and cytokine production. Stem Cells Transl Med 7:45-58. doi: 10.1002/sctm.17-0108 PMID: 29215199

Objective: To examine the potential utility of an alternative, mesenchymal-like cell (MSCs) source, derived from induced pluripotent stem cells, termed induced mesenchymal progenitor cells (MiMPCs) to produce bioactive factors and support nerve regeneration.

Summary: The findings suggest MiMPCs as a renewable, candidate source of therapeutic cells and a potential alternative to MSCs for peripheral nerve repair, in view of their ability to promote nerve growth by producing many of the same growth factors and cytokines as Schwann cells and signaling through critical neurotrophic pathways.

Usage: Immunofluorescence

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Lindborg JA, Mack M, Zigmond RE (2017) Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration. J Neurosci 37(43):10258-10277. doi: 10.1523/JNEUROSCI.2085-17.2017 PMID: 28912156

Objective: To characterize Wallerian degeneration (WD) in male Ccr2−/−mice and identify a compensatory mechanism of WD that is facilitated primarily by neutrophils.

Summary: The data have shown that neutrophils play an impressive role in myelin removal during WD. Neutrophil-specific depletion severely abates nerve debris clearance not only in Ccr2−/− mice, but in WT mice as well. The findings show a novel role for neutrophils that better elucidates the process of WD in the peripheral nervous system.

Usage: immunohistochemistry (1:400)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Cai S, Tsui YP, Tam KW, Shea GK, Chang RS, Ao Q, Shum DK, Chan YS (2017) Directed differentiation of human bone marrow stromal cells to fate-committed schwann cells. Stem Cell Reports 9(4):1097-1108. doi: 10.1016/j.stemcr.2017.08.004 PMID: 28890164

Objective: To create a protocol for in vitro derivation of fate-committed Schwann cells (SCs) from human bone marrow stromal cells (BMSCs).

Summary: This study demonstrates that the human bone marrow harbors neuro-ectodermal progenitors that can be enriched, expanded, and directed to differentiate into functionally mature, fate-committed SCs.

Usage: IF (1:500) and WB (1:500)

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Li G, Liu J, Wang Y, Yang K, Zhao M, Xiao Y, Wen X, Liu L (2017) LNGFR targets the Wnt/β-catenin pathway and promotes the osteogenic differentiation in rat ectomesenchymal stem cells. Sci Rep 7(1):11021. doi: 10.1038/s41598-017-11555-9 PMID: 28887537

Objective: To demonstrate that nuclear β-catenin was upregulated during ectomesenchymal stem cells (EMSC) osteogenic differentiation.

Summary: The data reveal that the low affinity nerve growth factor receptor (LNGFR) targets the Wnt/β-catenin pathway and positively regulates EMSC osteogenic differentiation, suggesting that Wnt/β-catenin pathway may be involved in the development of teeth and that the targeting Wnt/β-catenin pathway may have great potential for applications in dental tissue engineering regeneration.

Usage: Western blot

Related Products: NGFR (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)