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Neuropeptide Y and its involvement in chronic pain
Diaz-delCastillo M, Woldbye DPD, Heegaard AM (2018) Neuropeptide Y and its involvement in chronic pain. Neuroscience 387:162-169. doi: 10.1016/j.neuroscience.2017.08.050
Related Products: NPY-SAP (Cat. #IT-28)
Atopic dermatitis linked cytokine interleukin-31 induced itch mediated via a neuropeptide natriuretic polypeptide b
Pitake S, Ralph PC, DeBrecht J, Mishra SK (2018) Atopic dermatitis linked cytokine interleukin-31 induced itch mediated via a neuropeptide natriuretic polypeptide b. Acta Derm Venereol 98:795-796. doi: 10.2340/00015555-2977
Objective: To determine if NPPB is involved as a neuropeptide in IL-31-mediated itch in atopic dermatitis (AD) via natriuretic polypeptide receptor A (NPRA) in the spinal cord.
Summary: This study reveals an important role of neuropeptide NPPB in AD that could provide a therapeutic target for alleviating chronic itch associated with AD.
Usage: To further demonstrate the IL-31-mediated itch response by NPRA receptors expressed in the spinal cord, Nppb-SAP (5 μg) was used to eliminate neurons expressing NPRA receptors in the spinal cord.
Related Products: Nppb-SAP (Cat. #IT-69)
Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy.
Zhang Z, Jiang SM, Ma YP, Dai PL, Wang YN, Zou GM, Gao HM, Yang Y, Li WG (2019) Expression of the intrarenal angiotensin receptor and the role of renin-angiotensin system inhibitors in IgA nephropathy. Mol Cell Biochem 453:103-110. doi: 10.1007/s11010-018-3435-4 PMID: 30159797
Objective: To investigate the role of intrarenal renin-angiotensin system (RAS) in the development of human kidney disease. Patients with IgA nephropathy (IgAN) were screened and their clinical characteristics analyzed.
Summary: Overexpression of AT1R on the mesangial cells of IgAN patients is associated with mesangial cell proliferation, glomerular segmental sclerosis, and crescent formation.
Usage: immunohistochemistry (1:500)
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Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway
Shumilov K, Real MÁ, Valderrama-Carvajal A, Rivera A (2018) Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway. PLoS One 13:e0203135. doi: 10.1371/journal.pone.0203135
Objective: To increase knowledge in the role of the striosomal projection onto the dopamine neurons of the SNc and its impact on the nigrostriatal dopamine pathway.
Summary: Results highlight the key function of the striosomes for maintenance of the striatal dopamine tone and contribute to the understanding of their involvement in some neurological disorders such as Huntington’s disease.
Usage: Unilateral intrastriatal 2-μl injections of Dermorphin-SAP (17 μg/μl in saline) were performed to induce the selective ablation of MOR-expressing neurons in the striosomal compartment.
Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)
Indoleamine 2,3-dioxygenase-dependent expansion of T-regulatory cells maintains mucosal healing in ulcerative colitis
Acovic A, Simovic Markovic B, Gazdic M, Arsenijevic A, Jovicic N, Gajovic N, Jovanovic M, Zdravkovic N, Kanjevac T, Harrell CR, Fellabaum C, Dolicanin Z, Djonov V, Arsenijevic N, Lukic ML, Volarevic V (2018) Indoleamine 2,3-dioxygenase-dependent expansion of T-regulatory cells maintains mucosal healing in ulcerative colitis. Therap Adv Gastroenterol 11:1-22. doi: 10.1177/1756284818793558
Objective: To analyze the significance of the IDO:Treg axis for inducing and maintaining mucosal healing in ulcerative colitis (UC).
Summary: IDO-dependent expansion of endogenous Tregs should be explored as a new approach for induction and maintenance of mucosal healing in patients with UC.
Usage: DSS-treated BALB/c mice were injected with Anti-CD103-SAP (2 mg/kg, intraperitoneally).
Related Products: Anti-CD103-SAP (Cat. #IT-50)
Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina
Jo A, Xu J, Deniz S, Cherian S, DeVries SH, Zhu Y (2018) Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina. Front Neural Circuits 12:66. doi: 10.3389/fncir.2018.00066 PMID: 30186122
Objective: To obtain unambiguous information about retinal processing.
Summary: Results establish a foundation for future application of intersectional strategies in the retina and retino-recipient regions.
Usage: Immunohistochemistry 1:1000.
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In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons
Tao X, Li N, Liu F, Hu Y, Liu J, Zhang Y-M (2018) In vitro examination of microglia-neuron crosstalk with BV2 cells, and primary cultures of glia and hypothalamic neurons. Heliyon 4:e00730. doi: 10.1016/j.heliyon.2018.e00730 PMID: 30148218
Related Products: Corticotropin Releasing Hormone Rabbit Polyclonal (Cat. #AB-02)
Cholinergic modulation of spatial learning, memory and navigation.
Solari N, Hangya B (2018) Cholinergic modulation of spatial learning, memory and navigation. Eur J Neurosci 48:2199-2230. doi: 10.1111/ejn.14089
Related Products: 192-IgG-SAP (Cat. #IT-01), GAT1-SAP (Cat. #IT-32)
Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo
Kosykh A, Beilin A, Sukhinich K, Vorotelyak E (2018) Postnatal neural crest stem cells from hair follicle interact with nerve tissue in vitro and in vivo. Tissue Cell 54:94-104. doi: 10.1016/j.tice.2018.08.005 PMID: 30309515
Objective: To investigate the interaction between Neural crest stem cells that located in the postnatal hair follicle (HF-NCSC) and a nerve tissue (embryonic and adult).
Summary: HF-NCSC maintain their NC potency in the interaction with the embryonic central nerve system tissue. The migration capacity of the HF NCSC corresponds to the developmental stage but not a type of a nerve tissue present in the co-culture. In contrast, an adult brain interaction changes the HF-NCSC status and reduces the proliferation.
Usage: immunohistochemistry (1:50)
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The hot ‘n’ cold of cue-induced drug relapse
Pitchers KK, Sarter M, Robinson TE (2018) The hot ‘n’ cold of cue-induced drug relapse. Learn Mem 25:474-480. doi: 10.1101/lm.046995.117
Related Products: 192-IgG-SAP (Cat. #IT-01)