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The p75 receptor is associated with inflammatory thermal hypersensitivity.
Watanabe T, Ito T, Inoue G, Ohtori S, Kitajo K, Doya H, Takahashi K, Yamashita T (2008) The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res 86:3566-3574. doi: 10.1002/jnr.21808 PMID: 18709654
Summary: Inflammation, which can lead to pain hypersensitivity, not only elevates NGF levels, but also can increase the sensitivity of high-threshold receptors. NGF is thought to be a major contributor to heightened pain states due to inflammation, and in this work the authors investigated the role that the p75 neurotrophin receptor might play in NGF-induced hyperalgesia. 30 minutes prior to injection with Freund’s adjuvant, mice received 10 μl of polyclonal anti-p75 (Cat. #AB-N01) into the plantar surface of the paw. The antibody administration blocked hyperalgesia, indicating that p75 plays an important role in inflammation-induced hyperalgesia.
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells
Lee G, Kim H, Elkabetz Y, Al Shamy G, Panagiotakos G, Barberi T, Tabar V, Studer L (2007) Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat Biotechnol 25(12):1468-1475. doi: 10.1038/nbt1365 PMID: 18037878
Usage: Flow Cytometry cell sorting was performed using Anti-NGFr (p75).
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons.
Singh B, Henneberger C, Betances D, Arevalo MA, Rodríguez-Tébar A, Meier JC, Grantyn R (2006) Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons. J Neurosci 26(27):7189-7200. doi: 10.1523/JNEUROSCI.5474-05.2006 PMID: 16822976
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01), NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons.
Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, Berse B, Thies RS, Blusztajn JK (2005) Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A 102(19):6984-6989. doi: 10.1073/pnas.0502097102 PMID: 15870197
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01), NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)
Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
Pehar M, Cassina P, Vargas MR, Castellanos R, Viera L, Beckman JS, Estévez AG, Barbeito L (2004) Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem 89(2):464-473. doi: 10.1111/j.1471-4159.2004.02357.x PMID: 15056289
Summary: The role of p75-mediated activity evaluated with p75NTR blocking antibody. Motor neuron loss induced by reactive astrocytes was prevented by blocking the p75NTR.
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor.
Campagnolo L, Russo MA, Puglianiello A, Favale A, Siracusa G (2001) Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor. Biol Reprod 64(2):464-472. doi: 10.1095/biolreprod64.2.464 PMID: 11159348
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Early migratory rat neural crest cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function.
Bannerman P, Nichols W, Puhalla S, Oliver T, Berman M, Pleasure D (2000) Early migratory rat neural crest cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function. J Neurosci Res 61:605-615. doi: 10.1002/1097-4547(20000915)61:6<605::AID-JNR4>3.0.CO;2-U PMID: 10972957
Summary: Gap junctions are vital for intercellular communication, especially during development. Neural crest cells develop into several types of neural cells, often migrating as a mass of cells to their final destinations. Bannerman et al. use the anti-p75 antibody (Cat. #AB-N01) to confirm the presence of p75 in neural crest cells. The authors examine how crucial survival signals are communicated during migration and demonstrate that interfering with gap junction formation causes death of neural crest cells.
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Identification of a human olfactory ensheathing cell that can effect transplant mediated remyelination of demyelinated CNS axons.
Barnett SC, Alexander CL Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn KT, Papanastassiou V, Kennedy PG, Franklin RJ (2000) Identification of a human olfactory ensheathing cell that can effect transplant mediated remyelination of demyelinated CNS axons. Brain 123:1581-1588. doi: 10.1093/brain/123.8.1581 PMID: 10908188
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Adhesion molecule expression and phenotype of glial cells in the olfactory tract.
Barnett SC, Franceschini IA (1999) Adhesion molecule expression and phenotype of glial cells in the olfactory tract. (eds. Matsas R, Tsacopoulos M). The Functional Roles of Glial Cells in Health and Disease. Advances in Experimental Medicine and Biology. 468:297-307. Springer, Boston, MA. doi: 10.1007/978-1-4615-4685-6_24 PMID: 10635038
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms.
Huber LJ, Chao MV (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. Devel Biol 167:227-238. doi: 10.1006/dbio.1995.1019 PMID: 7851645
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)