Ma SY, Ciliax BJ, Stebbins G, Jaffar S, Joyce JN, Cochran EJ, Kordower JH, Mash DC, Levey AI, Mufson EJ (1999) Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. J Comp Neurol 409(1):25-37. doi: 10.1002/(sici)1096-9861(19990621)409:1<25::aid-cne3>3.0.co;2-e PMID: 10363709

Objective: To quantify the number of DAT immunostained neurons.

Summary: Findings demonstrate an age-related reduction in the number of substantia nigra DAT-immunoreactive neurons.

Usage: IHC (1:500)

Related Products: Dopamine Transporter Rat Monoclonal (DAT-ECD) (Cat. #AB-N17), Dopamine Transporter Rat Monoclonal (DAT-NT) (Cat. #AB-N18)

Sesack SR, Hawrylak VA, Matus C, Guido MA, Levey AI (1998) Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter. J Neurosci 18(7):2697-2708. doi: 10.1523/JNEUROSCI.18-07-02697.1998 PMID: 9502827

Objective: To determine whether the reportedly greater diffusion of dopamine in the rat prefrontal cortex (PFC) as compared with the striatum is associated with a more restricted axonal distribution of the cortical DAT protein.

Summary: Results suggest that considerable extracellular diffusion of dopamine in the prelimbic PFC may result, at least in part, from a paucity of DAT content in mesocortical dopamine axons, as well as a distribution of the DAT protein at a distance from synaptic release sites. Also, different populations of dopamine neurons may selectively target the DAT to different subcellular locations.

Usage: electron microscopy

Related Products: Dopamine Transporter Rat Monoclonal (DAT-NT) (Cat. #AB-N18)

Hersch SM, Yi H, Heilman CJ, Edwards RH, Levey AI (1997) Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. J Comp Neurol 388(2):211-227. PMID: 9368838

Usage: Western Blot (1:500) and IHC (1:100–1:250)

Related Products: Dopamine Transporter Rat Monoclonal (DAT-ECD) (Cat. #AB-N17), Dopamine Transporter Rat Monoclonal (DAT-NT) (Cat. #AB-N18)