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A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

Shen Q, Xu L, Li R, Wu G, Li S, Saw PE, Zhou Y, Xu X (2021) A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy. Chem Commun (Camb) 57(20):2563-2566. doi: 10.1039/d0cc07808e

Summary: This publication describes the development of a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compound G0–C14 for in vivo delivery of cytotoxic saporin and breast cancer therapy.

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