Ahmad A, Khan JM (2022) pH-sensitive endosomolytic peptides in gene and drug delivery: Endosomal escape and current challenges. Journal of Drug Delivery Science and Technology 76:103786. doi: 10.1016/j.jddst.2022.103786
Objective: To provide an overview on mechanism of endosomal escape of pH-sensitive endosomolytic peptides.
Summary: Discussion topics: the many forms of anionic and cationic pH-sensitive endosomolytic peptides (pSEPs) employed in gene/drug delivery for endosomal escape enhancement, the mechanisms by which pSEPs escape the endosome.