Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!

Konsman JP (2022) Cytokines in the Brain and Neuroinflammation: We Didn’t Starve the Fire!. Pharmaceuticals (Basel) 15(2):140. doi: 10.3390/ph15020140 PMID: 35215252

Summary: To test the role of IL-1 receptor brain macrophages, the work of Chaskiel et al. employed IL-1 coupled to the ribosome toxin, saporin, and administered this conjugate into forebrain ventricles to effectively reduce the number of CD163-positive perivascular macrophages with no reduction of food intake after subsequent IL-1beta administration.

See Also:

• Chaskiel L et al. Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus. Brain Behav Immun 81:560-573, 2019.