- We are highlighting a recent article. Congratulations to Ren et al. on your publication.
Ren X, Wang Y, Zhang Y (2025) Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice. Cell Discov 11:56. doi: 10.1038/s41421-025-00810-3 PMID: 40490480 - In this study, the authors used Streptavidin-ZAP (IT-27) with biotinylated CD150 antibody to selectively eliminate dysfunctional CD150-expressing hematopoietic stem cells.
- Hematopoietic stem cells (HSCs) are specialized cells found in the bone marrow that can develop into all types of blood cells and play a crucial role in maintaining blood tissue and repairing damage throughout a person’s life. However, aging leads to a decline in HSC function, characterized by the accumulation of dysfunctional HSCs and skewed differentiation towards the myeloid lineage which is a component of hematopoietic aging.
- Authors were able to show reducing the dysfunctional CD150 HSC population could be a strategy for alleviating aging-related phenotypes in aged mice.
- This article is a good example of using saporin conjugates in stem cell research.
- Also check out our new catalog product Anti-CD150-SAP (IT-103), which is a direct conjugate of Anti-CD150 and saporin.
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