a tool for eliminating cells that express NK3 (NKB receptor); targeted via neurokinin B peptide ([MePhe7]-NKB), eliminated via saporin

SKU: IT-63 Category: Product Size: 25 ug, 100 ug, 250 ug, 1 mg | Conjugate: saporin | Usage: eliminates cells |

An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NKB-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several locations, KNDy neurons reside only within the hypothalamic arcuate nucleus of many mammalian species and are critical for reproductive function. NKB-SAP can also be used to target and selectively destroy NK3 (NKB receptor)-expressing cells in other regions of the brain.

NKB-SAP specifically eliminates cells expressing the NK3 (NKB receptor). All other cells are left untouched.

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