An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NKB-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several locations, KNDy neurons reside only within the hypothalamic arcuate nucleus of many mammalian species and are critical for reproductive function. NKB-SAP can also be used to target and selectively destroy NK3 (NKB receptor)-expressing cells in other regions of the brain.
NKB-SAP (NK3-SAP) is a chemical conjugate of an analog of the neurokinin B peptide ([MePhe7]-NKB) and the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing the NK3 (NKB receptor).