NKB-SAP (NK3-SAP) [IT-63, KIT-63]

a tool for eliminating cells that express NK3 (NKB receptor); targeted via neurokinin B peptide ([MePhe7]-NKB), eliminated via saporin

SKU: IT-63 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Conjugate: saporin | Usage: eliminates cells |

An analog of the Neurokinin B peptide, [MePhe7]-NKB, is a selective agonist of the NK3 receptor. Conjugation of [MePhe7]-NKB to saporin (NKB-SAP) allows for the specific elimination of a subpopulation of neurons expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons) through their co-expression of the NK3 receptor. Although NK3 receptor expressing neurons reside in several locations, KNDy neurons reside only within the hypothalamic arcuate nucleus of many mammalian species and are critical for reproductive function. NKB-SAP can also be used to target and selectively destroy NK3 (NKB receptor)-expressing cells in other regions of the brain.

NKB-SAP (NK3-SAP) is a chemical conjugate of an analog of the neurokinin B peptide ([MePhe7]-NKB) and the ribosome-inactivating protein, saporin. It specifically eliminates cells expressing the NK3 (NKB receptor).

NKB-SAP is available individually (Cat. #IT-63) or as a kit (Cat. #KIT-63) which includes NKB-SAP, and Blank-SAP (Cat. #IT-21).

keywords: NKB, neurokinin B, NK3, NK3r, NK3 receptor, kisspeptin, dynorphin, KNDy neuron, analog, mePHe7-NKB, saporin, Hypothalamic arcuate nucleus, reproductive system, brain, neuroscience


There are no reviews yet.

Be the first to review “NKB-SAP (NK3-SAP) [IT-63, KIT-63]”

View Data Sheet

browse all references for this product | back to top

browse all protocols and calculators | back to top

Shopping Cart
Scroll to Top