Neurotensin-SAP [IT-56, KIT-56]

a tool for eliminating cells that express neurotensin receptor; targeted via neurotensin, eliminated via saporin

SKU: IT-56 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Conjugate: saporin | Usage: eliminates cells |

Neurotensin is a 13-amino-acid peptide found in the brain and spinal cord (first characterized by Carraway and Leeman). It is released by the hypothalamus and synthesized as part of a larger precursor protein that also includes the related neuropeptide neuromedin N. Neurotensin affects pituitary hormone release, interacts with the dopaminergic system, and is involved in vasodilation and hypotension. It can also modulate pain perception. Intrathecal neurotensin has also been shown to be anti-nociceptive.

Neurotensin-SAP is a chemical conjugate of neurotensin and the ribosome-inactivating protein, saporin. It specifically eliminates neurotensin receptor-expressing cells.

Neurotensin-SAP is available individually (Cat. #IT-56) or as a kit (Cat. #KIT-56) which includes Neurotensin-SAP and Blank-SAP (Cat. #IT-21).

keywords: Neurotensin, neurotensin receptor, high-affinity neurotensin receptor, NTSR-1, NTSR-2, NTSR-3, nueromedin N, saporin, pain, brain, neuroscience


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