CD103, also known as integrin, alpha-E (ITGAE) binds integrin beta 7 (ÌÙ7-ITGB7) to form the complete heterodimeric integrin molecule alphaEÌÙ7. The nondepleting CD103 monoclonal antibody, M290, binds a discrete and stable subset of human CD8+ cytotoxic T lymphocytes. Expression by these cells is initiated and maintained by bioactive TGF-ë_. Anti-CD103-SAP recognizes and eliminates cells expressing CD103. Elimination of cells expressing CD103 can help identify the role of integrin in promoting organ allograft rejection and in graft-versus-host disease.
Anti-CD103-SAP specifically eliminates cells that express CD103 in mouse.
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