Anti-CD103-SAP [IT-50, KIT-50]

CD103, also known as integrin, alpha-E (ITGAE) binds integrin beta 7 (ß7-ITGB7) to form the complete heterodimeric integrin molecule alphaEß7. The nondepleting CD103 monoclonal antibody, M290, binds a discrete and stable subset of CD8+ cytotoxic T lymphocytes. Expression by these cells is initiated and maintained by bioactive TGF-β. Anti-CD103-SAP recognizes and eliminates cells expressing CD103. Elimination of cells expressing CD103 can help identify the role of integrin in promoting organ allograft rejection and in graft-versus-host disease.

Anti-CD103-SAP is a chemical conjugate of a rat monoclonal antibody to CD103 (M290) and the ribosome-inactivating protein, saporin. Anti-CD103-SAP specifically eliminates cells that express CD103 in mouse.

Anti-CD103-SAP is available individually (Cat. #IT-50) or as a kit (Cat. #KIT-50) which includes Anti-CD103-SAP and Rat IgG-SAP (Cat. #IT-17).

keywords: CD103, integrin, alpha-E, ITGAE, integrin beta 7, ß7-ITGB7, alphaEß7, αEß7, alpha-EM290, TGF-ß, CD8+, T lymphocytes, saporin