Corticotropin-releasing hormone/factor (CRH/CRF) is the principal neuropeptide involved in regulating the stress response. It stimulates ACTH release from the pituitary gland. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically seen in depressed patients. CRF-SAP eliminates cells expressing the CRF1 receptor making it an effective tool to determine their neurobiological role(s). CRF-SAP is not suitable for retrograde transport.
CRF-SAP is a chemical conjugate of human/rat CRF and the ribosome-inactivating protein, saporin. It eliminates cells expressing the CRF1 receptor.